Physical-chemical Stability of the Extemporaneous Paracetamol Oral Suspension in Puccini Base.
Int J Pharm Compd
; 28(2): 151-155, 2024.
Article
in En
| MEDLINE
| ID: mdl-38604142
ABSTRACT
This study describes a new method for the preparation of extemporaneous paracetamol-based suspensions for pediatric and adult patients. This method allows the preparation of extemporaneous suspensions up to concentrations of 50 mg/mL by using a liquid base, named "Puccini". A high-pressure liquid chromatographic method was developed and validated for the determination of chemical stability of paracetamol when the formulations were stored at 4°C and 25°C. The chemical stability of the active pharmaceutical ingredient in the base was demonstrated for more than 90 days. Visual analyses of the formulations showed a phenomenon of precipitation at both storage temperatures, but the simple agitation of the formulations before its use re-established the formation of homogeneous suspensions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acetaminophen
Limits:
Adult
/
Child
/
Humans
Language:
En
Journal:
Int J Pharm Compd
Year:
2024
Document type:
Article
Affiliation country:
Italy