A microphysiological system for handling graphene related materials under flow conditions.
Nanoscale Horiz
; 9(6): 990-1001, 2024 05 29.
Article
in En
| MEDLINE
| ID: mdl-38606529
ABSTRACT
The field of nanotechnology has developed rapidly in recent decades due to its broad applications in many industrial and biomedical fields. Notably, 2D materials such as graphene-related materials (GRMs) have been extensively explored and, as such, their safety needs to be assessed. However, GRMs tend to deposit quickly, present low stability in aqueous solutions, and adsorb to plastic materials. Consequently, traditional approaches based on static assays facilitate their deposition and adsorption and fail to recreate human physiological conditions. Organ-on-a-chip (OOC) technology could, however, solve these drawbacks and lead to the development of microphysiological systems (MPSs) that mimic the microenvironment present in human tissues. In light of the above, in the present study a microfluidic system under flow conditions has been optimised to minimise graphene oxide (GO) and few-layer graphene (FLG) adsorption and deposition. For that purpose, a kidney-on-a-chip was developed and optimised to evaluate the effects of exposure to GO and FLG flakes at a sublethal dose under fluid flow conditions. In summary, MPSs are an innovative and precise tool for evaluating the effects of exposure to GRMs and other type of nanomaterials.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Graphite
Limits:
Animals
/
Humans
Language:
En
Journal:
Nanoscale Horiz
Year:
2024
Document type:
Article
Affiliation country:
Spain