Immunotherapy and the ovarian cancer microenvironment: Exploring potential strategies for enhanced treatment efficacy.
Immunology
; 173(1): 14-32, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-38618976
ABSTRACT
Despite progress in cancer immunotherapy, ovarian cancer (OC) prognosis continues to be disappointing. Recent studies have shed light on how not just tumour cells, but also the complex tumour microenvironment, contribute to this unfavourable outcome of OC immunotherapy. The complexities of the immune microenvironment categorize OC as a 'cold tumour'. Nonetheless, understanding the precise mechanisms through which the microenvironment influences the effectiveness of OC immunotherapy remains an ongoing scientific endeavour. This review primarily aims to dissect the inherent characteristics and behaviours of diverse cells within the immune microenvironment, along with an exploration into its reprogramming and metabolic changes. It is expected that these insights will elucidate the operational dynamics of the immune microenvironment in OC and lay a theoretical groundwork for improving the efficacy of immunotherapy in OC management.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Tumor Microenvironment
/
Immunotherapy
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Immunology
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United kingdom