Malformation of the endoplasmic reticulum system evolving into giant inclusions and Auer bodies in acute promyelocytic leukemia: an ultrastructural study of 6 cases.
Ultrastruct Pathol
; 48(3): 221-233, 2024 May 03.
Article
in En
| MEDLINE
| ID: mdl-38619116
ABSTRACT
The endoplasmic reticulumï¼ERï¼is the largest membranous network serving as a region for protein, lipid and steroid synthesis, transport and storage. Detailed information about ER-cisternae, ER-tubules and rough endoplasmic reticulum (rER) is scarce in human blood cells. This study describes a series of giant inclusions and Auer bodies in promyeloblasts in six patients with acute promyelocytic leukemia (APL), by light microscopy, transmission electron microscopy (TEM) and cytochemical stains. TEM revealed that giant inclusions and pro-Auer bodies were associated with rER and surrounded by tubular structures composed of degenerated or redundant membrane in promyeloblasts, which corresponded with elements of the ER system. This paper reveals that in the promyeloblasts of APL, ER is the source of and transforms progressively into giant inclusions and Auer bodies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukemia, Promyelocytic, Acute
/
Inclusion Bodies
/
Microscopy, Electron, Transmission
/
Endoplasmic Reticulum
Limits:
Adolescent
/
Adult
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Ultrastruct Pathol
Year:
2024
Document type:
Article
Affiliation country:
China