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Yeast Prion Protein Sup35 Initiates α-Synuclein Pathology in Parkinson's Disease.
Wang, Youcui; Li, Hui; Song, Ning; Xie, Junxia.
Affiliation
  • Wang Y; Institute of Brain Science and Disease, School of Basic Medicine, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, China.
  • Li H; Institute of Brain Science and Disease, School of Basic Medicine, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, China.
  • Song N; Institute of Brain Science and Disease, School of Basic Medicine, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, China.
  • Xie J; Institute of Brain Science and Disease, School of Basic Medicine, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, China.
Mov Disord ; 39(5): 766-767, 2024 May.
Article in En | MEDLINE | ID: mdl-38627965
ABSTRACT
Sinus infection of Saccharomyces cerevisiae accelerates the aggregation of α-synuclein (α-syn) in A53T mice, which was caused by prion protein Sup35. Sup35 promotes α-syn aggregation in vitro and in vivo and leads to Parkinson's disease (PD)-like motor impairment in wildtype mice, suggesting that the yeast Sup35 triggers α-syn pathology in PD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Peptide Termination Factors / Saccharomyces cerevisiae Proteins / Alpha-Synuclein Limits: Animals / Humans Language: En Journal: Mov Disord Journal subject: NEUROLOGIA Year: 2024 Document type: Article Affiliation country: China Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Peptide Termination Factors / Saccharomyces cerevisiae Proteins / Alpha-Synuclein Limits: Animals / Humans Language: En Journal: Mov Disord Journal subject: NEUROLOGIA Year: 2024 Document type: Article Affiliation country: China Country of publication: United States