Is preoperative weight reduction of living-donor liver transplant recipients and donors harmful to postoperative outcomes?
J Gastrointest Surg
; 28(7): 1033-1038, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38631611
ABSTRACT
PURPOSE:
Although the incidence of recipients and donors with overweight and obesity is increasing worldwide, few reports have focused on outcomes of preoperative weight reduction (WR) in living-donor liver transplantation (LDLT). Therefore, we examined the outcomes and the impact of WR on the postoperative course.METHODS:
We analyzed 217 consecutive LDLT procedures performed from 2017 to 2022. We divided the recipients and donors into a WR group and non-WR group.RESULTS:
Twenty-two recipients (10.1%) achieved WR (preoperative recipient WR [RWR] group), reducing their weight by 6.8% ± 6.0% within 2.2 ± 1.4 months with a significant decrease in body mass index (BMI) (P < .0001). The RWR group showed no significant differences in short-term postoperative outcomes (operative factors, postoperative liver function tests, amount of ascites, and morbidity) or in the graft survival rate as a long-term outcome (P = .24) compared with the non-RWR group. Forty-one donors (18.9%) achieved WR (preoperative donor WR [DWR] group), reducing their weight by 9.7% ± 6.3% within 3.2 ± 5.8 months with a significant decrease in BMI (P < .0001). Compared with the non-DWR group, the DWR group showed no significant differences in short-term postoperative outcomes between themselves and recipients or in the graft survival rate (P = .49). Furthermore, WR resulted in an increase to 32 donor-eligible and 6 recipient-eligible patients.CONCLUSION:
WR in LDLT recipients and donors had no harmful effect on postoperative outcomes and should lead to increase recipients' chance of undergoing LDLT and to expand the donor pool.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Postoperative Complications
/
Weight Loss
/
Body Mass Index
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Liver Transplantation
/
Living Donors
/
Graft Survival
Limits:
Adult
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
J Gastrointest Surg
Journal subject:
GASTROENTEROLOGIA
Year:
2024
Document type:
Article