Protective effects of COVID-19 vaccination in splenectomized patients with immune thrombocytopenia.
Br J Haematol
; 204(6): 2217-2221, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38632670
ABSTRACT
Splenectomy is an effective treatment for immune thrombocytopenia (ITP). The effect of COVID-19 vaccination on splenectomized patients with ITP during the COVID-19 pandemic has not been reported. Therefore, this study aimed to investigate the effect of COVID-19 vaccination on clinical outcomes in these patients. This was a longitudinal study of splenectomized patients with ITP. A total of 191 splenectomized patients were included in this study. After a median follow-up of 114 months, 146 (76.4%) patients had a sustained response to splenectomy. During COVID-19 infection, vaccinated patients showed a lower risk of severe infections (odds ratio [OR], 0.13; 95% confidence interval [CI] 0.05-0.36; p < 0.001), hospitalization (OR, 0.13; 95% CI, 0.04-0.48; p = 0.002), and ITP exacerbation (OR, 0.16; 95% CI, 0.04-0.67; p = 0.012). These findings indicate that COVID-19 vaccination plays a protective role in splenectomized patients with ITP.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Splenectomy
/
Purpura, Thrombocytopenic, Idiopathic
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COVID-19 Vaccines
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SARS-CoV-2
/
COVID-19
Limits:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Br J Haematol
Year:
2024
Document type:
Article
Affiliation country:
China