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Pretreatment and analysis techniques development of TKIs in biological samples for pharmacokinetic studies and therapeutic drug monitoring.
Chen, Lan; Zhang, Yuan; Zhang, Yi-Xin; Wang, Wei-Lai; Sun, De-Mei; Li, Peng-Yun; Feng, Xue-Song; Tan, Yue.
Affiliation
  • Chen L; School of Pharmacy, China Medical University, Shenyang, 110122, China.
  • Zhang Y; School of Pharmacy, China Medical University, Shenyang, 110122, China.
  • Zhang YX; School of Pharmacy, China Medical University, Shenyang, 110122, China.
  • Wang WL; School of Pharmacy, China Medical University, Shenyang, 110122, China.
  • Sun DM; School of Pharmacy, China Medical University, Shenyang, 110122, China.
  • Li PY; Institute of Pharmacology and Toxicology Institution, National Engineering Research Center for Strategic Drugs, Beijing, 100850, China.
  • Feng XS; School of Pharmacy, China Medical University, Shenyang, 110122, China.
  • Tan Y; Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, 110022, China.
J Pharm Anal ; 14(4): 100899, 2024 Apr.
Article in En | MEDLINE | ID: mdl-38634061
ABSTRACT
Tyrosine kinase inhibitors (TKIs) have emerged as the first-line small molecule drugs in many cancer therapies, exerting their effects by impeding aberrant cell growth and proliferation through the modulation of tyrosine kinase-mediated signaling pathways. However, there exists a substantial inter-individual variability in the concentrations of certain TKIs and their metabolites, which may render patients with compromised immune function susceptible to diverse infections despite receiving theoretically efficacious anticancer treatments, alongside other potential side effects or adverse reactions. Therefore, an urgent need exists for an up-to-date review concerning the biological matrices relevant to bioanalysis and the sampling methods, clinical pharmacokinetics, and therapeutic drug monitoring of different TKIs. This paper provides a comprehensive overview of the advancements in pretreatment methods, such as protein precipitation (PPT), liquid-liquid extraction (LLE), solid-phase extraction (SPE), micro-SPE (µ-SPE), magnetic SPE (MSPE), and vortex-assisted dispersive SPE (VA-DSPE) achieved since 2017. It also highlights the latest analysis techniques such as newly developed high performance liquid chromatography (HPLC) and high-resolution mass spectrometry (HRMS) methods, capillary electrophoresis (CE), gas chromatography (GC), supercritical fluid chromatography (SFC) procedures, surface plasmon resonance (SPR) assays as well as novel nanoprobes-based biosensing techniques. In addition, a comparison is made between the advantages and disadvantages of different approaches while presenting critical challenges and prospects in pharmacokinetic studies and therapeutic drug monitoring.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Pharm Anal Year: 2024 Document type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Pharm Anal Year: 2024 Document type: Article Affiliation country: China