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Treatment success in cats with chronic enteropathy is associated with a decrease in fecal calprotectin concentrations.
Heilmann, Romy M; Riggers, Denise S; Trewin, Isla; Köller, Gábor; Kathrani, Aarti.
Affiliation
  • Heilmann RM; Department for Small Animals, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany.
  • Riggers DS; Department for Small Animals, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany.
  • Trewin I; Department of Clinical Science and Services, Royal Veterinary College, London, United Kingdom.
  • Köller G; Department for Large Animals, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany.
  • Kathrani A; Department of Clinical Science and Services, Royal Veterinary College, London, United Kingdom.
Front Vet Sci ; 11: 1390681, 2024.
Article in En | MEDLINE | ID: mdl-38634105
ABSTRACT
Feline chronic enteropathies (FCE) are challenging to diagnose and monitor for progression and response to treatment. Fecal calprotectin might be a useful non-invasive marker to evaluate clinical endpoints of therapeutic monitoring in FCE. We evaluated fecal calprotectin concentrations in cats with FCE before and after initiation of treatment comprised of immunomodulation and/or dietary intervention. Included were 17 cats with FCE and 18 healthy controls. Clinical investigation of FCE cases included clinical severity grading (feline chronic enteropathy activity index, FCEAI) in all cats, abdominal ultrasonography in 15 cats, and gastrointestinal biopsies in 6 cats. Fecal calprotectin was measured in samples from 12 cats with FCE before treatment, all 17 FCE cats ≥6 weeks after treatment initiation, and all healthy controls. Fecal calprotectin concentrations in FCE cases before treatment (median 61 µg/g) were significantly higher than after treatment initiation (median 15 µg/g; p = 0.0098) and compared to controls (median 6 µg/g; p = 0.0235) and correlated with the FCEAI scores (ρ = 0.54, p = 0.0316). Fecal calprotectin concentrations after treatment initiation were higher with more severe duodenal/proximal jejunal pathology (ρ = 0.83, p = 0.0427) and shorter intervals between sampling time points (ρ = -0.54, p = 0.0250). Relevant decreases in initially increased fecal calprotectin concentrations are seen in cats with FCE on varying treatment strategies that significantly improve or have remission of clinical signs. This supports the utility of fecal calprotectin as a surrogate biomarker to assess disease severity in FCE cases. Further studies need to evaluate fecal calprotectin concentrations longitudinally in relation to mucosal healing vs. clinical response.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Vet Sci Year: 2024 Document type: Article Affiliation country: Germany Publication country: CH / SUIZA / SUÍÇA / SWITZERLAND

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Vet Sci Year: 2024 Document type: Article Affiliation country: Germany Publication country: CH / SUIZA / SUÍÇA / SWITZERLAND