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Enantioselective bioaccumulation and toxicological effects of chiral neonicotinoid sulfoxaflor in rats.
Fang, Yaofeng; Lv, Shengchen; Xiao, Shouchun; Hou, Haonan; Yao, Jianing; Cao, Yue; He, Bingying; Liu, Xueke; Wang, Peng; Liu, Donghui; Zhou, Zhiqiang.
Affiliation
  • Fang Y; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, PR China.
  • Lv S; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, PR China.
  • Xiao S; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, PR China.
  • Hou H; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, PR China.
  • Yao J; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, PR China.
  • Cao Y; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, PR China.
  • He B; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, PR China.
  • Liu X; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, PR China. Electronic address: liuxueke@cau.edu.cn.
  • Wang P; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, PR China.
  • Liu D; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, PR China.
  • Zhou Z; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, PR China.
Chemosphere ; 358: 142065, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38636916
ABSTRACT
Sulfoxaflor is a widely used fourth-generation neonicotinoid pesticide, which has been detected in biological and environmental samples. Sulfoxaflor can potentially be exposed to humans via the food chain, thus understanding its toxic effects and enantioselective bioaccumulation is crucial. In this study, toxicokinetics, bioaccumulation, tissue distribution and enantiomeric profiles of sulfoxaflor in rats were investigated through single oral exposure and 28-days continuous exposure experiment. Sulfoxaflor mainly accumulated in liver and kidney, and the (-)-2R,3R-sulfoxaflor and (-)-2S,3R-sulfoxaflor had higher enrichment than their enantiomers in rats. The toxicological effects were evaluated after 28-days exposure. Slight inflammation in liver and kidney were observed by histopathology. Sphingolipid, amino acid, and vitamin B6 metabolism pathways were significantly disturbed in metabonomics analysis. These toxicities were in compliance with dose-dependent effects. These results improve understanding of enantioselective bioaccumulation and the potential health risk of sulfoxaflor.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfur Compounds / Liver Limits: Animals Language: En Journal: Chemosphere Year: 2024 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfur Compounds / Liver Limits: Animals Language: En Journal: Chemosphere Year: 2024 Document type: Article Country of publication: United kingdom