High-dose Vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF-&#954;B and PI3K/AKT/mTOR signaling pathways in rats.

Cui, Ya-Nan; Tian, Na; Luo, Yan-Hai; Zhao, Ji-Jun; Bi, Cheng-Fei; Gou, Yi; Liu, Jia; Feng, Ke; Zhang, Jun-Fei

High-dose Vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF-κB and PI3K/AKT/mTOR signaling pathways in rats.

Cui, Ya-Nan; Tian, Na; Luo, Yan-Hai; Zhao, Ji-Jun; Bi, Cheng-Fei; Gou, Yi; Liu, Jia; Feng, Ke; Zhang, Jun-Fei.

Affiliation

Cui YN; Medical Records and Statistics Room, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750000, China.
Tian N; Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750000, China.
Luo YH; School of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia 750000, China.
Zhao JJ; Department of Pathology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750000, China.
Bi CF; Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750000, China.
Gou Y; Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750000, China.
Liu J; School of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia 750000, China.
Feng K; Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750000, China.
Zhang JF; School of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia 750000, China.

Aging (Albany NY) ; 16(8): 6937-6953, 2024 04 19.

Article in En | MEDLINE | ID: mdl-38643461

Subject(s)

Ascorbic Acid; Autophagy; Heart Injuries; Myocardium; Sepsis; Animals; Rats; Anti-Inflammatory Agents/pharmacology; Anti-Inflammatory Agents/administration & dosage; Apoptosis/drug effects; Ascorbic Acid/pharmacology; Ascorbic Acid/therapeutic use; Autophagy/drug effects; Heart Injuries/drug therapy; Heart Injuries/etiology; Heart Injuries/metabolism; Myocardium/metabolism; Myocardium/pathology; NF-kappa B/drug effects; NF-kappa B/metabolism; Phosphatidylinositol 3-Kinases/drug effects; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/drug effects; Proto-Oncogene Proteins c-akt/metabolism; Rats, Sprague-Dawley; Sepsis/drug therapy; Sepsis/complications; Sepsis/metabolism; Signal Transduction/drug effects; TOR Serine-Threonine Kinases/drug effects; TOR Serine-Threonine Kinases/metabolism

Key words

High-dose Vitamin C; MAPK; NF-κB and PI3K/AKT/mTOR signaling pathways; apoptosis; autophagy; inflammatory; sepsis-induced myocardial injury

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ascorbic Acid / Autophagy / Sepsis / Heart Injuries / Myocardium Limits: Animals Language: En Journal: Aging (Albany NY) Journal subject: GERIATRIA Year: 2024 Document type: Article Affiliation country: China Country of publication: United States

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