Obesity is associated with acute kidney injury in ST-segment-elevation myocardial infarction undergoing percutaneous coronary intervention: A national representative cohort study.
Catheter Cardiovasc Interv
; 103(6): 897-908, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38654635
ABSTRACT
BACKGROUND:
Acute kidney injury (AKI) is a frequent and potentially life-threatening complication after percutaneous coronary intervention (PCI) in patients with ST-segment-elevation myocardial infarction (STEMI). However, the relationship between obesity and the risk of AKI in this specific patient population has not been previously examined.METHODS:
We queried the National Inpatient Sample (2016-2019) using ICD-10 codes to obtain a sample of adults with STEMI undergoing PCI. All patients were further subcategorized into obese and nonobese cohorts. The primary outcome was the incidence of AKI. Multivariate regression analysis was performed to assess the impact of obesity on AKI. The consistency of this correlation between subgroups was investigated using subgroup analysis and interaction testing.RESULTS:
A total of 62,599 (weighted national estimate of 529,016) patients were identified, of which 9.80% (n = 6137) had AKI. Obesity comprised 19.78% (n = 1214) of the AKI cohort. Obese patients were on average younger, male, white, and had more comorbidities. Additionally, there was a significant positive association between obesity and AKI incidence (adjusted odds ratio [aOR] 1.24, 95% confidence interval [CI] 1.15-1.34), which was more pronounced in female patients (aOR 1.56, 95% CI 1.33-1.82, p < 0.001, p-interaction = 0.008). The AKI incidence in these patients increased steadily during the 4-year study period, and it was consistently higher in obese patients than in nonobese patients (p-trend < 0.001 for all).CONCLUSIONS:
Obesity was independently associated with a greater risk of AKI among adults with STEMI undergoing PCI, particularly in female patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Databases, Factual
/
Acute Kidney Injury
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Percutaneous Coronary Intervention
/
ST Elevation Myocardial Infarction
/
Obesity
Limits:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Journal:
Catheter Cardiovasc Interv
Journal subject:
CARDIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United States