Limited prognostic role of routine serum markers (AP, CEA, LDH and NSE) in oligorecurrent prostate cancer patients undergoing PSMA-radioguided surgery.
World J Urol
; 42(1): 256, 2024 Apr 24.
Article
in En
| MEDLINE
| ID: mdl-38656636
ABSTRACT
INTRODUCTION:
We evaluated the prognostic role of pre-salvage prostate-specific membrane antigen-radioguided surgery (PSMA-RGS) serum levels of alkaline phosphatase (AP), carcinoembryonic antigen (CEA), lactate dehydrogenase (LDH), and neuron-specific enolase (NSE). MATERIALS ANDMETHODS:
Patients who consecutively underwent PSMA-RGS for prostate cancer (PCa) oligorecurrence between January 2019 and January 2022 were selected. Biomarkers were assessed one day before surgery. Cox regression and logistic regression models tested the relationship between biochemical recurrence-free survival (BFS), 6- and 12-month biochemical recurrence (BCR), and several independent variables, including biomarkers.RESULTS:
153 consecutive patients were analyzed. In the univariable Cox regression analysis, none of the biomarkers achieved predictor status (AP hazard ratio [HR] = 1.03, 95% CI 0.99, 1.01; p = 0.19; CEA HR = 1.73, 95% CI 0.94, 1.21; p = 0.34; LDH HR = 1.01, 95% CI 1.00, 1.01; p = 0.05; NSE HR = 1.02, 95% CI 0.98, 1.06; p = 0.39). The only independent predictor of BFS was the number of positive lesions on PSMA PET (HR = 1.17, 95% CI 1.02, 1.30; p = 0.03). The number of positive lesions was confirmed as independent predictor for BCR within 6 and 12 months (BCR < 6 months odds ratio [OR] = 1.1, 95% CI 1.0, 1.3; p = 0.04; BCR < 12 months OR = 1.1, 95% CI 1.0, 1.3; p = 0.04).CONCLUSION:
The assessment of AP, CEA, LDH, and NSE before salvage PSMA-RGS showed no prognostic impact. Further studies are needed to identify possible predictors that will optimize patient selection for salvage PSMA-RGS.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphopyruvate Hydratase
/
Prostatic Neoplasms
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Carcinoembryonic Antigen
/
Biomarkers, Tumor
/
Alkaline Phosphatase
/
L-Lactate Dehydrogenase
/
Neoplasm Recurrence, Local
Limits:
Aged
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
World J Urol
Year:
2024
Document type:
Article
Affiliation country:
Germany