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Post-COVID Trajectory of Pentraxin 3 Plasma Levels Over 6 Months and Their Association with the Risk of Developing Post-Acute Depression and Anxiety.
De Lorenzo, Rebecca; Mazza, Mario G; Sciorati, Clara; Leone, Roberto; Scavello, Francesco; Palladini, Mariagrazia; Merolla, Aurora; Ciceri, Fabio; Bottazzi, Barbara; Garlanda, Cecilia; Benedetti, Francesco; Rovere-Querini, Patrizia; Manfredi, Angelo A.
Affiliation
  • De Lorenzo R; Vita-Salute San Raffaele University, Milan, Italy.
  • Mazza MG; Unit of Innate Immunity and Tissue Remodeling, Department of Internal Medicine, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Sciorati C; Psychiatry and Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, San Raffaele Turro, Via Stamira d'Ancona 20, 20127, Milan, Italy. mazza.mariogennaro@hsr.it.
  • Leone R; Unit of Innate Immunity and Tissue Remodeling, Department of Internal Medicine, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Scavello F; IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Palladini M; IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Merolla A; Vita-Salute San Raffaele University, Milan, Italy.
  • Ciceri F; Psychiatry and Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, San Raffaele Turro, Via Stamira d'Ancona 20, 20127, Milan, Italy.
  • Bottazzi B; Vita-Salute San Raffaele University, Milan, Italy.
  • Garlanda C; Unit of Innate Immunity and Tissue Remodeling, Department of Internal Medicine, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Benedetti F; Vita-Salute San Raffaele University, Milan, Italy.
  • Rovere-Querini P; Hematology and Bone Marrow Transplant Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Manfredi AA; IRCCS Humanitas Research Hospital, Rozzano, Italy.
CNS Drugs ; 38(6): 459-472, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38658499
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Clinical manifestations of coronavirus disease 2019 (COVID-19) often persist after acute disease resolution. Underlying molecular mechanisms are unclear. The objective of this original article was to longitudinally measure plasma levels of markers of the innate immune response to investigate whether they associate with and predict post-COVID symptomatology.

METHODS:

Adult patients with previous severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection during the first pandemic wave who underwent the 6-month multidisciplinary follow-up were included. Plasma levels of pentraxin 3 (PTX3), the complement components C3a and C5a, and chitinase-3 like-protein-1 (CHI3L1) were measured at hospital admission during acute disease (baseline) and at 1 and 6 months after hospital discharge. Associations with post-COVID-19 sequelae at 6 months were investigated using descriptive statistic and multiple regression models.

RESULTS:

Ninety-four COVID-19 patients were included. Baseline PTX3, C5a, C3a, and CHI3L1 did not predict post-COVID-19 sequelae. The extent of the reduction of PTX3 over time (delta PTX3) was associated with lower depressive and anxiety symptoms at 6 months (both p < 0.05). When entering sex, age, need for intensive care unit or non-invasive ventilation during hospital stay, psychiatric history, and baseline PTX3 as nuisance covariates into a generalized linear model (GLM), the difference between baseline and 6-month PTX3 levels (delta PTX3) significantly predicted depression (χ2 = 4.66, p = 0.031) and anxiety (χ2 = 4.68, p = 0.031) at 6 months. No differences in PTX3 levels or PTX3 delta were found in patients with or without persistent or new-onset other COVID-19 symptoms or signs at 6 months. Plasma levels of C3a, C5a, and CHI3L1 did not correlate with PTX3 levels at either time point and failed to associate with residual or de novo respiratory or systemic clinical manifestations of the disease at 6 months.

CONCLUSIONS:

A lower reduction of plasma PTX3 after acute COVID-19 associates with the presence of depression and anxiety, suggesting an involvement of inflammation in post-COVID-19 psychopathology and a potential role of PTX3 as a biomarker.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / C-Reactive Protein / Serum Amyloid P-Component / Biomarkers / COVID-19 / Post-Acute COVID-19 Syndrome Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: CNS Drugs Journal subject: FARMACOLOGIA / NEUROLOGIA / TERAPIA POR MEDICAMENTOS Year: 2024 Document type: Article Affiliation country: Italy

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / C-Reactive Protein / Serum Amyloid P-Component / Biomarkers / COVID-19 / Post-Acute COVID-19 Syndrome Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: CNS Drugs Journal subject: FARMACOLOGIA / NEUROLOGIA / TERAPIA POR MEDICAMENTOS Year: 2024 Document type: Article Affiliation country: Italy