Curcumin nanogel and its efficacy against oxidative stress and inflammation in rat models of ischemic stroke.
Nanomedicine (Lond)
; 19(12): 1069-1085, 2024.
Article
in En
| MEDLINE
| ID: mdl-38661738
ABSTRACT
Aim:
The study was designed to develop and analyze curcumin nanoparticles.Methods:
Curcumin nanoparticles were formulated and evaluated. Their efficacy in protecting against brain damage was investigated in a rat model of ischemic stroke, considering motor function, muscle strength and antioxidant enzyme activity.Results:
Curcumin nanoparticles displayed a zeta potential of -55 ± 13.5 mV and an average particle size of 51.40 ± 21.70 nm. In ischemic stroke rat models, curcumin nanoparticle treatment significantly improved motor functions, and muscle strength and increased the activities of antioxidant enzymes like glutathione peroxidase, glutathione, glutathione S-transferase, superoxide dismutase and catalase, reducing oxidative stress and inflammation.Conclusion:
Curcumin nanoparticles showed significant neuroprotective effects in ischemic stroke models.
[Box see text].
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxidative Stress
/
Curcumin
/
Disease Models, Animal
/
Ischemic Stroke
/
Inflammation
/
Antioxidants
Limits:
Animals
Language:
En
Journal:
Nanomedicine (Lond)
Year:
2024
Document type:
Article
Affiliation country:
Saudi Arabia
Country of publication:
United kingdom