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Bi-2-(2-phenethyl)chromone derivatives from agarwood of Aquilaria filaria in the Philippines.
Yang, Hong-Run; Wang, Hao; Wang, Pei; Liu, Fang-Zheng; Chai, Hong-Xing; Cai, Cai-Hong; Yang, Li; Yuan, Jing-Zhe; Jiang, Bei; Mei, Wen-Li; Dai, Hao-Fu.
Affiliation
  • Yang HR; International Joint Research Center of Agarwood, Haikou, 571101, PR China; Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, Dali, 671000, PR China.
  • Wang H; International Joint Research Center of Agarwood, Haikou, 571101, PR China.
  • Wang P; International Joint Research Center of Agarwood, Haikou, 571101, PR China.
  • Liu FZ; International Joint Research Center of Agarwood, Haikou, 571101, PR China; Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, Dali, 671000, PR China.
  • Chai HX; International Joint Research Center of Agarwood, Haikou, 571101, PR China; Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, Dali, 671000, PR China.
  • Cai CH; International Joint Research Center of Agarwood, Haikou, 571101, PR China.
  • Yang L; International Joint Research Center of Agarwood, Haikou, 571101, PR China.
  • Yuan JZ; International Joint Research Center of Agarwood, Haikou, 571101, PR China.
  • Jiang B; Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, Dali, 671000, PR China.
  • Mei WL; National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, PR China; International Joint Research Center of Agarwood, Haikou, 571101, PR China. Electronic address: meiwenli@itbb.org.cn.
  • Dai HF; National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, PR China; International Joint Research Center of Agarwood, Haikou, 571101, PR China; Yunnan Key Laboratory of Screening and Resea
Phytochemistry ; 222: 114108, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38663825
ABSTRACT
Twelve undescribed 2-(2-phenethyl)chromone dimers (1-12) were isolated from EtOAc extract of agarwood originating from Aquilaria filaria in the Philippines, guided by a UHPLC-MS analysis. Their structures were elucidated by 1D NMR, 2D NMR, and HR-ESI-MS spectra. The absolute configuration of 2-(2-phenylethyl)chromone dimers was determined by single-crystal X-ray diffraction analysis and comparison of the experimental and calculated ECD spectra. Compounds 1, 2, 5 and 9-12 exhibited potent to moderate anti-inflammatory activity with IC50 values in the range of 22.43 ± 0.86 to 53.88 ± 4.06 µM.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wood / Chromones / Thymelaeaceae Limits: Animals Country/Region as subject: Asia Language: En Journal: Phytochemistry Year: 2024 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wood / Chromones / Thymelaeaceae Limits: Animals Country/Region as subject: Asia Language: En Journal: Phytochemistry Year: 2024 Document type: Article Country of publication: United kingdom