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Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection.
Marchal, Astrid; Cirulli, Elizabeth T; Neveux, Iva; Bellos, Evangelos; Thwaites, Ryan S; Schiabor Barrett, Kelly M; Zhang, Yu; Nemes-Bokun, Ivana; Kalinova, Mariya; Catchpole, Andrew; Tangye, Stuart G; Spaan, András N; Lack, Justin B; Ghosn, Jade; Burdet, Charles; Gorochov, Guy; Tubach, Florence; Hausfater, Pierre; Dalgard, Clifton L; Zhang, Shen-Ying; Zhang, Qian; Chiu, Christopher; Fellay, Jacques; Grzymski, Joseph J; Sancho-Shimizu, Vanessa; Abel, Laurent; Casanova, Jean-Laurent; Cobat, Aurélie; Bolze, Alexandre.
Affiliation
  • Marchal A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; University Paris Cité, Imagine Institute, Paris, France.
  • Cirulli ET; Helix, San Mateo, CA, USA.
  • Neveux I; Department of Internal Medicine, University of Nevada School of Medicine, Reno, NV, USA.
  • Bellos E; Department of Infectious Disease, Imperial College London, London, UK.
  • Thwaites RS; National Heart and Lung Institute, Imperial College London, London, UK.
  • Schiabor Barrett KM; Helix, San Mateo, CA, USA.
  • Zhang Y; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, Bethesda, MD, USA.
  • Nemes-Bokun I; Department of Infectious Disease, Imperial College London, London, UK.
  • Kalinova M; hVIVO Services Ltd, London, UK.
  • Catchpole A; hVIVO Services Ltd, London, UK.
  • Tangye SG; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, New South Wales, Australia.
  • Spaan AN; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • Lack JB; NIAID Collaborative Bioinformatics Resource, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, MD, USA.
  • Ghosn J; Infection, Antimicrobials, Modelling, Evolution (IAME), INSERM, UMR1137, University Paris Cité, Paris, France; AP-HP, Bichat-Claude Bernard Hospital, Infectious and Tropical Diseases Department, Paris, France.
  • Burdet C; Infection, Antimicrobials, Modelling, Evolution (IAME), INSERM, UMR1137, University Paris Cité, Paris, France; AP-HP, Hôpital Bichat, Centre d'Investigation Clinique, INSERM CIC 1425, Paris, France; Département Epidémiologie, Biostatistiques et Recherche Clinique, Hôpital Bichat, Assistance Publique
  • Gorochov G; Sorbonne Université, INSERM Centre d'Immunologie et des Maladies Infectieuses, CIMI-Paris, Département d'immunologie Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Tubach F; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpital Pitié-Salpêtrière, Département de Santé Publique, Unitéde Recherche Clinique PSL-CFX, CIC-1901, Paris, France.
  • Hausfater P; Emergency Department, Hôpital Pitié-Salpêtrière, APHP-Sorbonne Université, Paris, France; GRC-14 BIOSFAST Sorbonne Université, UMR INSERM 1135, CIMI, Sorbonne Université, Paris, France.
  • Dalgard CL; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
  • Zhang SY; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; University Paris Cité, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
  • Zhang Q; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; University Paris Cité, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
  • Chiu C; Department of Infectious Disease, Imperial College London, London, UK.
  • Fellay J; School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Grzymski JJ; Department of Internal Medicine, University of Nevada School of Medicine, Reno, NV, USA; Renown Health, Reno, NV, USA.
  • Sancho-Shimizu V; Department of Infectious Disease, Imperial College London, London, UK; Centre for Paediatrics and Child Health, Faculty of Medicine, Imperial College London, London, UK.
  • Abel L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; University Paris Cité, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
  • Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; University Paris Cité, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA; Department of Pe
  • Cobat A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; University Paris Cité, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Electronic addre
  • Bolze A; Helix, San Mateo, CA, USA. Electronic address: alexandre.bolze@gmail.com.
HGG Adv ; 5(3): 100300, 2024 Jul 18.
Article in En | MEDLINE | ID: mdl-38678364
ABSTRACT
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗1501 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗1501, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗1501 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asymptomatic Infections / SARS-CoV-2 / COVID-19 Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: HGG Adv Year: 2024 Document type: Article Affiliation country: France Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asymptomatic Infections / SARS-CoV-2 / COVID-19 Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: HGG Adv Year: 2024 Document type: Article Affiliation country: France Country of publication: United States