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Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder.
Ho, Natalie C W; Bethlehem, Richard A I; Seidlitz, Jakob; Nogovitsyn, Nikita; Metzak, Paul; Ballester, Pedro L; Hassel, Stefanie; Rotzinger, Susan; Poppenk, Jordan; Lam, Raymond W; Taylor, Valerie H; Milev, Roumen; Bullmore, Edward T; Alexander-Bloch, Aaron F; Frey, Benicio N; Harkness, Kate L; Addington, Jean; Kennedy, Sidney H; Dunlop, Katharine.
Affiliation
  • Ho NCW; Keenan Research Centre for Biomedical Research, Unity Health Toronto, Toronto, Ontario, Canada; Centre for Depression & Suicide Studies, Unity Health Toronto, Toronto, Ontario, Canada; Faculty of Arts and Sciences, University of Toronto, Toronto, Ontario, Canada.
  • Bethlehem RAI; Department of Psychology, University of Cambridge, Cambridge, United Kingdom.
  • Seidlitz J; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania; Lifespan Brain Institute, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Institute of Translational Medicine & Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania; Department
  • Nogovitsyn N; Centre for Depression & Suicide Studies, Unity Health Toronto, Toronto, Ontario, Canada.
  • Metzak P; Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
  • Ballester PL; Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Hassel S; Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, Alberta, Canada.
  • Rotzinger S; Keenan Research Centre for Biomedical Research, Unity Health Toronto, Toronto, Ontario, Canada; Centre for Depression & Suicide Studies, Unity Health Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Mood Disorders Treatment and Researc
  • Poppenk J; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada; Department of Psychology, Queen's University, Kingston, Ontario, Canada; School of Computing, Queen's University, Kingston, Ontario, Canada.
  • Lam RW; Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
  • Taylor VH; Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, Alberta, Canada.
  • Milev R; Department of Psychology, Queen's University, Kingston, Ontario, Canada; Department of Psychiatry, Queen's University, Kingston, Ontario, Canada; Providence Care Hospital, Kingston, Ontario, Canada.
  • Bullmore ET; Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
  • Alexander-Bloch AF; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania; Lifespan Brain Institute, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Institute of Translational Medicine & Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania; Department
  • Frey BN; Mood Disorders Treatment and Research Centre, St Joseph's Healthcare, Hamilton, Ontario, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
  • Harkness KL; Department of Psychology, Queen's University, Kingston, Ontario, Canada; Department of Psychiatry, Queen's University, Kingston, Ontario, Canada.
  • Addington J; Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, Alberta, Canada.
  • Kennedy SH; Keenan Research Centre for Biomedical Research, Unity Health Toronto, Toronto, Ontario, Canada; Centre for Depression & Suicide Studies, Unity Health Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Dunlop K; Keenan Research Centre for Biomedical Research, Unity Health Toronto, Toronto, Ontario, Canada; Centre for Depression & Suicide Studies, Unity Health Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: katharine.dunlop
Article in En | MEDLINE | ID: mdl-38679324
ABSTRACT

BACKGROUND:

Patients with major depressive disorder (MDD) can present with altered brain structure and deficits in cognitive function similar to those seen in aging. However, the interaction between age-related brain changes and brain development in MDD remains understudied. In a cohort of adolescents and adults with and without MDD, we assessed brain aging differences and associations through a newly developed tool that quantifies normative neurodevelopmental trajectories.

METHODS:

A total of 304 participants with MDD and 236 control participants without depression were recruited and scanned from 3 studies under the Canadian Biomarker Integration Network for Depression. Volumetric data were used to generate brain centile scores, which were examined for 1) differences between participants with MDD and control participants; 2) differences between individuals with versus without severe childhood maltreatment; and 3) correlations with depressive symptom severity, neurocognitive assessment domains, and escitalopram treatment response.

RESULTS:

Brain centiles were significantly lower in the MDD group than in the control group. Brain centile was also significantly correlated with working memory in the control group but not the MDD group. No significant associations were observed between depression severity or antidepressant treatment response and brain centiles. Likewise, childhood maltreatment history did not significantly affect brain centiles.

CONCLUSIONS:

Consistent with previous work on machine learning models that predict brain age, brain centile scores differed in people diagnosed with MDD, and MDD was associated with differential relationships between centile scores and working memory. The results support the notion of atypical development and aging in MDD, with implications for neurocognitive deficits associated with aging-related cognitive function.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Year: 2024 Document type: Article Affiliation country: Canada

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Year: 2024 Document type: Article Affiliation country: Canada
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