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Injectable hydrogel harnessing foreskin mesenchymal stem cell-derived extracellular vesicles for treatment of chronic diabetic skin wounds.
Xu, Chang; Cao, Jin-Feng; Pei, Yue; Kim, Yujin; Moon, Huiyeon; Fan, Chui-Qin; Liao, Mao-Chuan; Wang, Xing-Yu; Yao, Fei; Zhang, Yu-Jun; Zhang, Shao-Hui; Zhang, Jian; Li, Jian-Zhang; Kim, Jong Seung; Ma, Lian; Xie, Zhong-Jian.
Affiliation
  • Xu C; Institute of Pediatrics, Shenzhen Children's Hospital, Clinical Medical College of Southern University of Science and Technology, Shenzhen 518038, China.
  • Cao JF; Beijing Key Laboratory of Wood Science and Engineering, Beijing Forestry University, Beijing 100083, China; Key Laboratory of Wood Material Science and Application (Beijing Forestry University), Ministry of Education, Beijing 100083, China.
  • Pei Y; Institute of Pediatrics, Shenzhen Children's Hospital, Clinical Medical College of Southern University of Science and Technology, Shenzhen 518038, China.
  • Kim Y; Department of Chemistry, Korea University, Seoul 02841, Republic of Korea.
  • Moon H; Department of Chemistry, Korea University, Seoul 02841, Republic of Korea.
  • Fan CQ; Institute of Pediatrics, Shenzhen Children's Hospital, Clinical Medical College of Southern University of Science and Technology, Shenzhen 518038, China.
  • Liao MC; Institute of Pediatrics, Shenzhen Children's Hospital, Clinical Medical College of Southern University of Science and Technology, Shenzhen 518038, China.
  • Wang XY; Department of Emergency, ChangYang Tujia Autonomous County People's Hospital, Yichang 443000, China.
  • Yao F; Eye Center of Xiangya Hospital, Central South University, Changsha 410000, China.
  • Zhang YJ; Institute of Pediatrics, Shenzhen Children's Hospital, Clinical Medical College of Southern University of Science and Technology, Shenzhen 518038, China.
  • Zhang SH; Institute of Materials Science and Devices, School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China.
  • Zhang J; Institute of Materials Science and Devices, School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China.
  • Li JZ; Beijing Key Laboratory of Wood Science and Engineering, Beijing Forestry University, Beijing 100083, China; Key Laboratory of Wood Material Science and Application (Beijing Forestry University), Ministry of Education, Beijing 100083, China. Electronic address: lijzh@bjfu.edu.cn.
  • Kim JS; Department of Chemistry, Korea University, Seoul 02841, Republic of Korea. Electronic address: jongskim@korea.ac.kr.
  • Ma L; Institute of Pediatrics, Shenzhen Children's Hospital, Clinical Medical College of Southern University of Science and Technology, Shenzhen 518038, China; Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen 518038, China; Department of Pediatrics, The Third Affifiliated Hosp
  • Xie ZJ; Institute of Pediatrics, Shenzhen Children's Hospital, Clinical Medical College of Southern University of Science and Technology, Shenzhen 518038, China; Shenzhen International Institute for Biomedical Research, Shenzhen 518116, Guangdong, China. Electronic address: xiezj2022@sustech.edu.cn.
J Control Release ; 370: 339-353, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38685383
ABSTRACT
Chronic skin wounds are a serious complication of diabetes with a high incidence rate, which can lead to disability or even death. Previous studies have shown that mesenchymal stem cells derived extracellular vesicles (EVs) have beneficial effects on wound healing. However, the human foreskin mesenchymal stem cell (FSMSCs)-derived extracellular vesicle (FM-EV) has not yet been isolated and characterized. Furthermore, the limited supply and short lifespan of EVs also hinder their practical use. In this study, we developed an injectable dual-physical cross-linking hydrogel (PSiW) with self-healing, adhesive, and antibacterial properties, using polyvinylpyrrolidone and silicotungstic acid to load FM-EV. The EVs were evenly distributed in the hydrogel and continuously released. In vivo and vitro tests demonstrated that the synergistic effect of EVs and hydrogel could significantly promote the repair of diabetic wounds by regulating macrophage polarization, promoting angiogenesis, and improving the microenvironment. Overall, the obtained EVs-loaded hydrogels developed in this work exhibited promising applicability for the repair of chronic skin wounds in diabetes patients.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wound Healing / Hydrogels / Foreskin / Mesenchymal Stem Cells / Extracellular Vesicles Limits: Animals / Humans / Male Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2024 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wound Healing / Hydrogels / Foreskin / Mesenchymal Stem Cells / Extracellular Vesicles Limits: Animals / Humans / Male Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2024 Document type: Article Affiliation country: China