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An AIE-based fluorescent probe to detect peroxynitrite levels in human serum and its cellular imaging.
Kim, Jaewon; Yoo, Jiyoung; Kim, Byungkook; Lee, Kyung-Woo; Kim, Sunghyun; Hong, Sukwon; Kim, Jong Seung.
Affiliation
  • Kim J; Department of Chemistry, Korea University, Seoul, 02841, Korea. jongskim@korea.ac.kr.
  • Yoo J; Department of Chemistry, Korea University, Seoul, 02841, Korea. jongskim@korea.ac.kr.
  • Kim B; Department of Chemistry, Korea University, Seoul, 02841, Korea. jongskim@korea.ac.kr.
  • Lee KW; Department of Chemistry, Korea University, Seoul, 02841, Korea. jongskim@korea.ac.kr.
  • Kim S; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea. shong@gist.ac.kr.
  • Hong S; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea. shong@gist.ac.kr.
  • Kim JS; Department of Chemistry, Korea University, Seoul, 02841, Korea. jongskim@korea.ac.kr.
Chem Commun (Camb) ; 60(41): 5443-5446, 2024 May 16.
Article in En | MEDLINE | ID: mdl-38686636
ABSTRACT
An AIE-based fluorescent probe was designed to evaluate peroxynitrite levels in complex biological samples. The newly synthesized hydrazone-conjugated probe fluoresces strongly in the presence of peroxynitrite. Clinically, the peroxynitrite levels can be measured in human serum and cellular mitochondria with an LOD of 6.5 nM by fluorescence imaging in vitro.
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peroxynitrous Acid / Optical Imaging / Fluorescent Dyes Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peroxynitrous Acid / Optical Imaging / Fluorescent Dyes Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Document type: Article