Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer.
Biomacromolecules
; 25(5): 2770-2779, 2024 May 13.
Article
in En
| MEDLINE
| ID: mdl-38687975
ABSTRACT
Drug repurposing uses approved drugs as candidate anticancer therapeutics, harnesses previous research and development efforts, and benefits from available clinically suitable formulations and evidence of patient tolerability. In this work, the drug used clinically to treat chronic alcoholism, disulfiram (DSF), was studied for its antitumor efficacy in a copper-dependent manner. The combination of DSF and copper could achieve a tumor cell growth inhibition effect comparable to those of 5-fluorouracil and taxol on head and neck cancer cells. Both bulk dendrimer hydrogel and microsized dendrimer hydrogel particles were utilized for the localized sustained release of copper in the tumor site. The localized sustained release of copper facilitated the tumor inhibition effect following intratumoral injection in a mouse's head and neck cancer model.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Copper
/
Delayed-Action Preparations
/
Disulfiram
/
Head and Neck Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Biomacromolecules
Journal subject:
BIOLOGIA MOLECULAR
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United States