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Water-Mediated On-Demand Detachable Solid-State Adhesive of Porous Hydroxyapatite for Internal Organ Retractions.
Okada, Masahiro; Xie, Shi Chao; Kobayashi, Yusuke; Yanagimoto, Hiroaki; Tsugawa, Daisuke; Tanaka, Masaru; Nakano, Takayoshi; Fukumoto, Takumi; Matsumoto, Takuya.
Affiliation
  • Okada M; Department of Biomaterials, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama, 700-8558, Japan.
  • Xie SC; Department of Biomaterials, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama, 700-8558, Japan.
  • Kobayashi Y; Department of Biomaterials, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama, 700-8558, Japan.
  • Yanagimoto H; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-Cho, Chuou-Ku, Kobe City, Hyogo, 650-0017, Japan.
  • Tsugawa D; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-Cho, Chuou-Ku, Kobe City, Hyogo, 650-0017, Japan.
  • Tanaka M; Soft Materials Chemistry, Institute of Material Chemistry and Engineering, Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka City, Fukuoka, 819-0395, Japan.
  • Nakano T; Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita City, Osaka, 565-0871, Japan.
  • Fukumoto T; Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-Cho, Chuou-Ku, Kobe City, Hyogo, 650-0017, Japan.
  • Matsumoto T; Department of Biomaterials, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama, 700-8558, Japan.
Adv Healthc Mater ; : e2304616, 2024 May 01.
Article in En | MEDLINE | ID: mdl-38691405
ABSTRACT
Novel adhesives for biological tissues offer an advanced surgical approach. Here, the authors report the development and application of solid-state adhesives consisting of porous hydroxyapatite (HAp) biocompatible ceramics as novel internal organ retractors. The operational principles of the porous solid-state adhesives are experimentally established in terms of water migration from biological soft tissues into the pores of the adhesives, and their performance is evaluated on several soft tissues with different hydration states. As an example of practical medical utility, HAp adhesive devices demonstrate the holding ability of porcine livers and on-demand detachability in vivo, showing great potential as internal organ retractors in laparoscopic surgery.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Adv Healthc Mater Year: 2024 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Adv Healthc Mater Year: 2024 Document type: Article Affiliation country: Japan