Functions and mechanisms of enzymes assembling lignans and norlignans.
Curr Opin Chem Biol
; 80: 102462, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38692182
ABSTRACT
Lignans and norlignans are distributed throughout the plant kingdom and exhibit diverse chemical structures and biological properties that offer potential for therapeutic use. Originating from the phenylpropanoid biosynthesis pathway, their characteristic carbon architectures are formed through unique enzyme catalysis, featuring regio- and stereoselective C-C bond forming processes. Despite extensive research on these plant natural products, their biosynthetic pathways, and enzyme mechanisms remain enigmatic. This review highlights recent advancements in elucidating the functions and mechanisms of the biosynthetic enzymes responsible for constructing the distinct carbon frameworks of lignans and norlignans.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lignans
Language:
En
Journal:
Curr Opin Chem Biol
Journal subject:
BIOQUIMICA
Year:
2024
Document type:
Article