Appendectomy and the Risk of Parkinson's Disease: A Korean Nationwide Study.
Mov Disord Clin Pract
; 11(6): 704-707, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38696328
ABSTRACT
BACKGROUND:
The vermiform appendix is considered a potential reservoir for the abnormal α-synuclein aggregate in Parkinson's disease (PD). Previous epidemiologic evidence on the association between appendectomy and PD risk remains inconclusive, especially outside the Western world.OBJECTIVES:
To investigate the association between appendectomy and PD risk in Korea.METHODS:
Among 703,831 eligible adult subjects in the National Health Insurance Service sample cohort, we identified 16,122 patients who underwent appendectomy. The rest formed the control group. PD risk was assessed using time-dependent Cox regression analyses.RESULTS:
The appendectomy group did not have altered risk of PD compared with the control group in either unadjusted [hazard ratio (HR) 1.32, 95% confidence interval (CI) 0.97-1.80, P = 0.08] or adjusted model (HR 1.42, CI 0.88-2.30, P = 0.15). No further statistical difference appeared when stratified by sex.CONCLUSIONS:
Appendectomy is not associated with altered risk of PD in the Korean population.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Appendectomy
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Mov Disord Clin Pract
Year:
2024
Document type:
Article
Affiliation country:
Canada