Causal Relationship Between Endometriosis and Pelvic Inflammatory Diseases: Mendelian Randomization Study.
Int J Womens Health
; 16: 727-735, 2024.
Article
in En
| MEDLINE
| ID: mdl-38699517
ABSTRACT
Objective:
This study explores the causal relationship between endometriosis and pelvic inflammatory diseases (PID).Methods:
The study utilized genome-wide association study (GWAS) datasets for endometriosis ("finn-b-N14_ENDOMETRIOSIS") and PID ("finn-b-N14_OTHFEMPELINF"). Subsequently, two-sample Mendelian randomization (MR) analyses were conducted using inverse variance weighting (IVW), Egger regression (MR-Egger), and weighted median (WM) methods. Heterogeneity was evaluated using Cochran's Q test, and in case of detected outliers, they were removed for re-evaluation of MR causality.Results:
From the endometriosis GWAS dataset, 33 single nucleotide polymorphisms (SNPs) were selected as instrumental variables. All three methods, IVW (OR = 1.39, P < 1×10-8), MR-Egger (OR = 1.41, P = 0.003), and WM (OR = 1.37, P = 1.16×10-5) confirmed a causal relationship between endometriosis and PID. The association between endometriosis and pelvic inflammation remained unaffected by the exclusion of individual SNPs. Lastly, Cochran's Q test and funnel plots showed no evidence of SNP asymmetry.Conclusion:
The results of the MR analysis support a potential causal relationship between endometriosis and an increased risk of PID.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Int J Womens Health
Year:
2024
Document type:
Article