Aspirin Metabolites and Mammographic Breast Density in Premenopausal Women.
Cancer Epidemiol Biomarkers Prev
; 33(8): 1126-1128, 2024 Aug 01.
Article
in En
| MEDLINE
| ID: mdl-38700429
ABSTRACT
BACKGROUND:
Studies investigating the associations of self-reported aspirin use and mammographic breast density (MBD) have reported conflicting results. Therefore, we investigated the associations of aspirin metabolites with MBD in premenopausal women.METHODS:
We performed this study on 705 premenopausal women who had a fasting blood draw for metabolomic profiling. We performed covariate-adjusted linear regression models to calculate the least square means of volumetric measures of MBD [volumetric percent density (VPD), dense volume (DV), and nondense volume (NDV)] by quartiles of aspirin metabolites [salicyluric glucuronide, 2-hydroxyhippurate (salicylurate), salicylate, and 2,6-dihydroxybenzoic acid].RESULTS:
Approximately 13% of participants reported taking aspirin in the past 12 months. Aspirin users had higher levels of 2-hydroxyhippurate (salicylurate), salicylate, and salicyluric glucuronide (peak area) than nonusers, but only the mean peak area of salicyluric glucuronide was increased by both dose (1-2 tablets per day = 1,140,663.7 and ≥3 tablets per day = 1,380,476.0) and frequency (days per week 1 day = 888,129.3, 2-3 days = 1,199,897.9, and ≥4 days = 1,654,637.0). Aspirin metabolites were not monotonically associated with VPD, DV, or NDV.CONCLUSIONS:
Given the null results, additional research investigating the associations of aspirin metabolites in breast tissue and MBD is necessary. Impact Elucidating the determinants of MBD, a strong risk factor for breast cancer, can play an important role in breast cancer prevention. Future studies should determine the associations of nonaspirin NSAID metabolites with MBD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Aspirin
/
Premenopause
/
Breast Density
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Cancer Epidemiol Biomarkers Prev
/
Cancer epidemiol. biomark. prev
/
Cancer epidemiology, biomarkers and prevention
Journal subject:
BIOQUIMICA
/
EPIDEMIOLOGIA
/
NEOPLASIAS
Year:
2024
Document type:
Article
Country of publication:
United States