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[Effects of Rhodiola rosea injection on intrapulmonary shunt and blood IL-6 and TNF-α levels during single lung ventilation in patients undergoing radical resection of esophageal cancer].
Liu, X; Hu, H; Fang, J; Huang, L; Cheng, X.
Affiliation
  • Liu X; Department of Anesthesiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
  • Hu H; Department of Anesthesiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
  • Fang J; Department of Anesthesiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
  • Huang L; Department of Anesthesiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
  • Cheng X; Department of Anesthesiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Nan Fang Yi Ke Da Xue Xue Bao ; 44(4): 706-711, 2024 Apr 20.
Article in Zh | MEDLINE | ID: mdl-38708504
ABSTRACT

OBJECTIVE:

To explore the effects of Rhodiola rosea injection on pulmonary shunt and serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels during single lung ventilation in patients undergoing radical resection of esophageal cancer.

METHODS:

Forty-six patients undergoing radical operation for esophageal cancer were randomized equally into control group and Rhodiola rosea injection group. In the Rhodiola group, 10 mL of Rhodiola rosea injection was added into 250 mL of normal saline or 5% glucose solution for slow intravenous infusion, and normal saline of the same volume was used in the control group after the patients entered the operation room. At T0, T1 and T3, PaO2 of the patient was recorded and 2 mL of deep venous blood was collected for determination of serum TNF-α and IL-6 levels. The incidence of postoperative atelectasis of the patients was recorded.

RESULTS:

Compared with those in the control group, the patients receiving Rhodiola rosea injection had significantly higher PaO2 and Qs/Qt at T1 and T2 (P<0.05) and lower serum IL-6 and TNF-α levels at T3 (P<0.05). No significant difference in the incidence of postoperative atelectasis was observed between the two groups (P>0.05).

CONCLUSION:

Rhodiola rosea injection before anesthesia induction can reduce intrapulmonary shunt during single lung ventilation, improve oxygenation, reduce serum IL-6 and TNF-α levels, and alleviate intraoperative lung injury in patients undergoing radical resection of esophageal cancer.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Esophageal Neoplasms / Interleukin-6 / Tumor Necrosis Factor-alpha / Rhodiola / One-Lung Ventilation Limits: Female / Humans / Male / Middle aged Language: Zh Journal: Nan Fang Yi Ke Da Xue Xue Bao Year: 2024 Document type: Article Affiliation country: China Country of publication: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Esophageal Neoplasms / Interleukin-6 / Tumor Necrosis Factor-alpha / Rhodiola / One-Lung Ventilation Limits: Female / Humans / Male / Middle aged Language: Zh Journal: Nan Fang Yi Ke Da Xue Xue Bao Year: 2024 Document type: Article Affiliation country: China Country of publication: China