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Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK.
Campbell, Cori; Wang, Tingyan; Smith, David A; Freeman, Oliver; Noble, Theresa; Várnai, Kinga A; Harris, Steve; Salih, Hizni; Roadknight, Gail; Little, Stephanie; Glampson, Ben; Mercuri, Luca; Papadimitriou, Dimitri; Jones, Christopher R; Taylor, Vince; Chaudhry, Afzal; Phan, Hang; Borca, Florina; Olza, Josune; Warricker, Frazer; Romão, Luis; Ramlakhan, David; English, Louise; Klenerman, Paul; Andersson, Monique I; Collier, Jane; Nastouli, Eleni; Khakoo, Salim I; Gelson, William; Cooke, Graham S; Woods, Kerrie; Davies, Jim; Barnes, Eleanor; Matthews, Philippa C.
Affiliation
  • Campbell C; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Wang T; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Smith DA; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Freeman O; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Noble T; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Várnai KA; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Harris S; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Salih H; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Roadknight G; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Little S; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Glampson B; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Mercuri L; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Papadimitriou D; Department of Computer Science, University of Oxford, Oxford, UK.
  • Jones CR; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Taylor V; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Chaudhry A; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Phan H; NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK.
  • Borca F; NIHR Imperial Biomedical Research Centre, London, UK.
  • Olza J; NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK.
  • Warricker F; NIHR Imperial Biomedical Research Centre, London, UK.
  • Romão L; NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK.
  • Ramlakhan D; NIHR Imperial Biomedical Research Centre, London, UK.
  • English L; Department of Infectious Disease, Imperial College London, London, UK.
  • Klenerman P; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Andersson MI; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Collier J; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Nastouli E; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Khakoo SI; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Gelson W; University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Cooke GS; University College London Hospitals NHS Foundation Trust, London, UK.
  • Woods K; University College London Hospitals NHS Foundation Trust, London, UK.
  • Davies J; University College London Hospitals NHS Foundation Trust, London, UK.
  • Barnes E; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Matthews PC; Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Wellcome Open Res ; 7: 51, 2022.
Article in En | MEDLINE | ID: mdl-38721280
ABSTRACT

Background:

To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarkers used for routine surveillance (alanine transferase [ALT] and HBV viral load).

Methods:

We used anonymized electronic health record data from the National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) pipeline representing five UK National Health Service (NHS) Trusts.

Results:

We report significant reductions in surveillance of both biomarkers during the pandemic compared to pre-COVID-19 years, both in terms of the proportion of patients who had ≥1 measurement annually, and the mean number of measurements per patient.

Conclusions:

These results demonstrate the real-time utility of HIC data in monitoring health-care provision, and support interventions to provide catch-up services to minimise the impact of the pandemic. Further investigation is required to determine whether these disruptions will be associated with increased rates of adverse chronic HBV outcomes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Wellcome Open Res Year: 2022 Document type: Article Affiliation country: United kingdom
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Wellcome Open Res Year: 2022 Document type: Article Affiliation country: United kingdom