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Poly(methylmethacrylate-co-dimethyl acrylamide)-silver nanocomposite prevents biofilm formation in medical devices.
Perasoli, Fernanda B; B Silva, Luan S; C Figueiredo, Bruna I; Pinto, Isabelle C; F Amaro, Lorrane J; S Almeida Bastos, Juliana C; Carneiro, Simone P; R Araújo, Vânia P; G Beato, Felipe R; M Barboza, Ana P; M Teixeira, Luiz F; Gallagher, Maurice P; Bradley, Mark; Venkateswaran, Seshasailam; H Dos Santos, Orlando D.
Affiliation
  • Perasoli FB; Laboratório de Fitotecnologia, Departamento de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
  • B Silva LS; Laboratório de Fitotecnologia, Departamento de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
  • C Figueiredo BI; Laboratório de Fitotecnologia, Departamento de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
  • Pinto IC; Laboratório de Fitotecnologia, Departamento de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
  • F Amaro LJ; Laboratório de Fitotecnologia, Departamento de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
  • S Almeida Bastos JC; Laboratório de Fitotecnologia, Departamento de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
  • Carneiro SP; Laboratório de Fitotecnologia, Departamento de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
  • R Araújo VP; Nano Lab, Departamento de Engenharia Metalúrgica e de Materiais, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
  • G Beato FR; Laboratório de Microscopia, Departamento de Física, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
  • M Barboza AP; Laboratório de Microscopia, Departamento de Física, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
  • M Teixeira LF; Laboratório de Fitotecnologia, Departamento de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
  • Gallagher MP; School of Biological Sciences, University of Edinburgh, King's Buildings, David Brewster Road, Edinburgh, EH9 3FJ, UK.
  • Bradley M; Precision Healthcare University Research Institute, Queen Mary University of London, Empire House, London, E1 1HH, UK.
  • Venkateswaran S; Precision Healthcare University Research Institute, Queen Mary University of London, Empire House, London, E1 1HH, UK.
  • H Dos Santos OD; Laboratório de Fitotecnologia, Departamento de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Nanomedicine (Lond) ; 19(14): 1285-1296, 2024.
Article in En | MEDLINE | ID: mdl-38722243
ABSTRACT

Aim:

To investigate whether medical devices coated with a synthesized nanocomposite of poly(methylmethacrylate-co-dimethyl acrylamide) (PMMDMA) and silver nanoparticles (AgNPs) could improve their antibiofilm and antimicrobial activities. We also investigated the nanocomposite's safety. Materials &

methods:

The nanocomposite was synthesized and characterized using analytical techniques. Medical devices coated with the nanocomposite were evaluated for bacterial adhesion and hemolytic activity in vitro.

Results:

The nanocomposite formation was demonstrated with the incorporation of AgNPs into the polymer matrix. The nanocomposite proved to be nonhemolytic and significantly inhibited bacterial biofilm formation.

Conclusion:

The PMMDMA-AgNPs nanocomposite was more effective in preventing biofilm formation than PMMDMA alone and is a promising strategy for coating medical devices and reducing mortality due to hospital-acquired infections.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Silver / Biofilms / Nanocomposites / Metal Nanoparticles Limits: Humans Language: En Journal: Nanomedicine (Lond) Year: 2024 Document type: Article Affiliation country: Brazil
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Silver / Biofilms / Nanocomposites / Metal Nanoparticles Limits: Humans Language: En Journal: Nanomedicine (Lond) Year: 2024 Document type: Article Affiliation country: Brazil