Genetic influence on treatment outcomes in patients with pain-related temporomandibular disorders.
J Oral Rehabil
; 51(8): 1542-1554, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38725226
ABSTRACT
BACKGROUND:
Single nucleotide polymorphisms (SNPs) may influence pain susceptibility and impact treatment response in pain-related temporomandibular disorders (TMDp).OBJECTIVE:
Explore the role of COMT (rs4646310, rs6269, rs4818, rs4680) and OPRM1 (rs1799971) genotypes in regulating treatment response.METHODS:
Sixty TMDp patients (55 females and 5 males), diagnosed with the Diagnostic Criteria for TMD (DC/TMD), underwent standardised treatment (information and education, home physical therapy, occlusal splint) for 6 months. Treatment outcomes included pain intensity, pain-free mouth opening, jaw functional limitation, depression, and anxiety. Genotyping for COMT and OPRM1 SNPs was performed using DNA from buccal mucosa swabs and TaqMan assays. Statistical analysis was carried out to compare the changes in treatment outcomes and the influence of genotypes on treatment response.RESULTS:
Significantly less pain reduction was observed in minor allele carriers of rs4646310, and rs4680 compared to dominant homozygous (p < .025). Minor allele carriers of rs1799971 and rs4646310 demonstrated worsening in pain-free mouth opening while dominant homozygous exhibited improvement (p < .025). Significantly less anxiety reduction was observed in minor allele carriers of rs4646310 compared to dominant homozygous (p = .003). Of the all variables assessed in the regression model, carrying a minor allele of rs1799971 predicted a poorer treatment response considering pain-free mouth opening while carrying a minor allele of rs4646310 predicted less pain and less anxiety reduction.CONCLUSION:
Our findings indicate that certain SNP variants of the COMT and OPRM1 genes were associated with poorer treatment response and may therefore play a significant role in the classification of TMDp patients. Also, assessment of patient genotype could potentially aid in predicting treatment response.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain Measurement
/
Facial Pain
/
Temporomandibular Joint Disorders
/
Catechol O-Methyltransferase
/
Receptors, Opioid, mu
/
Polymorphism, Single Nucleotide
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Genotype
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Oral Rehabil
Year:
2024
Document type:
Article
Affiliation country:
Croatia
Country of publication:
United kingdom