Hyaluronic Acid as a LYVE-1 Receptor Ligand in the Lymphatic System of Healthy Human Skin.
Bull Exp Biol Med
; 176(5): 636-639, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38727953
ABSTRACT
Immunohistochemical detection of the LYVE-1 marker in healthy human full-thickness skin (the epidermis and the dermis) was carried out. LYVE-1 expression was found in the endothelium of lymphatic capillaries located in the papillary dermis, in the endothelium of larger lymphatic vessels of the reticular dermis, and in fibroblasts, which indicates their joint participation in hyaluronan metabolism. LYVE-1+ staining detected for the first time in cells of the stratum basale, the stratum spinosum, and the stratum granulosum of healthy human epidermis indicates their participation in hyaluronan metabolism and allows us to consider the spaces between epidermis cells as prelimphatics.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
/
Vesicular Transport Proteins
/
Lymphatic Vessels
/
Epidermis
/
Hyaluronic Acid
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Bull Exp Biol Med
Year:
2024
Document type:
Article
Affiliation country:
RUSSIA
Country of publication:
United States