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The Los Angeles motor scale (LAMS) is independently associated with CT perfusion collateral status markers.
Lakhani, Dhairya A; Mehta, Tejas R; Balar, Aneri B; Koneru, Manisha; Wen, Sijin; Ozkara, Burak Berksu; Caplan, Justin; Dmytriw, Adam A; Wang, Richard; Lu, Hanzhang; Hoseinyazdi, Meisam; Nabi, Mehreen; Mazumdar, Ishan; Cho, Andrew; Chen, Kevin; Sepehri, Sadra; Hyson, Nathan; Xu, Risheng; Urrutia, Victor; Luna, Licia; Hillis, Argye H; Heit, Jeremy J; Albers, Greg W; Rai, Ansaar T; Faizy, Tobias D; Wintermark, Max; Nael, Kambiz; Yedavalli, Vivek S.
Affiliation
  • Lakhani DA; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA. Electronic address: dhairyalakhani@gmail.com.
  • Mehta TR; Department of Neurology, University of missouri, Columbia, MO, USA.
  • Balar AB; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Koneru M; Cooper Medical School of Rowan University, Camden, NJ, USA.
  • Wen S; Department of Biostatistics, West Virginia University, Morgantown, WV, USA.
  • Ozkara BB; Department of Neuroradiology, MD Anderson Medical Center, Houston, TX.
  • Caplan J; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
  • Dmytriw AA; Department of Radiology, Harvard Medical School, Boston, MA, USA.
  • Wang R; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Lu H; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Hoseinyazdi M; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Nabi M; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Mazumdar I; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Cho A; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Chen K; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Sepehri S; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Hyson N; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Xu R; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Urrutia V; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Luna L; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Hillis AH; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
  • Heit JJ; Department of Neurology, Stanford University, Stanford, CA, USA.
  • Albers GW; Department of Neurology, Stanford University, Stanford, CA, USA.
  • Rai AT; Department of Neuroradiology, West Virginia University, Morgantown, WV, USA.
  • Faizy TD; Department of Radiology, Neuroendovascular Division - University Medical Center Münster, Germany.
  • Wintermark M; Department of Neuroradiology, MD Anderson Medical Center, Houston, TX.
  • Nael K; Division of Neuroradiology, Department of Radiology, University of California San Francisco, CA, USA.
  • Yedavalli VS; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
J Clin Neurosci ; 125: 32-37, 2024 Jul.
Article in En | MEDLINE | ID: mdl-38735251
ABSTRACT
BACKGROUND AND

AIM:

The Los Angeles Motor Scale (LAMS) is an objective tool that has been used to rapidly assess and predict the presence of large vessel occlusion (LVO) in the pre-hospital setting successfully in several studies. However, studies assessing the relationship between LAMS score and CT perfusion collateral status (CS) markers such as cerebral blood volume (CBV) index, and hypoperfusion intensity ratio (HIR) are sparse. Our study therefore aims to assess the association of admission LAMS score with established CTP CS markers CBV Index and HIR in AIS-LVO cases. MATERIALS AND

METHODS:

In this prospectively collected, retrospectively reviewed analysis, inclusion criteria were as follows a) CT angiography (CTA) confirmed anterior circulation LVO from 9/1/2017 to 10/01/2023, and b) diagnostic CT perfusion (CTP). Logistic regression analysis was performed to assess the relationship between admission LAMS with CTP CS markers HIR and CBV Index. p ≤ 0.05 was considered significant.

RESULTS:

In total, 285 consecutive patients (median age = 69 years; 56 % female) met our inclusion criteria. Multivariable logistic regression analysis adjusting for sex, age, ASPECTS, tPA, premorbid mRS, admission NIH stroke scale, prior history of TIA, stroke, atrial fibrillation, diabetes mellitus, hyperlipidemia, coronary artery disease and hypertension, admission LAMS was found to be independently associated with CBV Index (adjusted OR0.82, p < 0.01), and HIR (adjusted OR0.59, p < 0.05).

CONCLUSION:

LAMS is independently associated with CTP CS markers, CBV index and HIR. This finding suggests that LAMS may also provide an indirect estimate of CS.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Collateral Circulation Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Clin Neurosci Journal subject: NEUROLOGIA Year: 2024 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Collateral Circulation Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Clin Neurosci Journal subject: NEUROLOGIA Year: 2024 Document type: Article