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The ameliorative effect of vinpocetine against gentamicin-induced uterine-injury in rats involves the inflammasome/caspase-1/IL-1ß pathway.
Geddawy, Ayman; Attya, Mina Ezzat; Hegazy, AbdelRahman; AbdElhaseeb, Mostafa Kamal; Fawzy, Michael Atef; Atta, Medhat; Ali, Fatma F; Abdelzaher, Walaa Yehia.
Affiliation
  • Geddawy A; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61511, Egypt.
  • Attya ME; Department of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, 11942, Al Kharj, Saudi Arabia.
  • Hegazy A; Department of Pathology, Faculty of Medicine, Minia University, Minia, 61511, Egypt.
  • AbdElhaseeb MK; Department of Obstetrics & Gynecology, Faculty of Medicine, Minia University, Minia, 61511, Egypt.
  • Fawzy MA; Department of Obstetrics & Gynecology, Faculty of Medicine, Minia University, Minia, 61511, Egypt.
  • Atta M; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, 61511, Egypt.
  • Ali FF; Department of Anatomy, Faculty of Medicine, Minia University, Minia, 61511, Egypt.
  • Abdelzaher WY; Medical Physiology Department, Faculty of Medicine, Minia University, Minia, 61511, Egypt.
Mol Biol Rep ; 51(1): 655, 2024 May 13.
Article in En | MEDLINE | ID: mdl-38739285
ABSTRACT

BACKGROUND:

There is limited data regarding the hazardous effect of gentamicin (GM) on the uterus and whether or not vinpocetine (Vinpo) ameliorates it. The present study aimed to identify the possible protective effect of Vinpo in GM-induced uterine injury in rats.

METHODS:

Female rats were assorted in control-group, Vinpo-group, GM-group, and Vinpo plus GM group. Serum and uterine GM concentration were measured. Uterine oxidative stress parameters besides inflammatory and apoptotic biomarkers were evaluated. Uterine histopathological examination and interlukin-1beta (IL-1ß) immune-histochemical study were detected.

RESULTS:

GM significantly increased uterine oxidative stress, inflammatory and apoptotic biomarkers. Histopathological picture of uterine damage and increased IL-1ß immunoexpression were detected. Vinpo significantly ameliorated the distributed GM concentration, oxidative stress, inflammatory and apoptotic biomarkers with a prompt improvement in histopathological picture and a decrease in IL-1ß immunoexpression.

CONCLUSION:

Vinpo protective effect against GM-induced uterine injury involves modulation of inflammasome/caspase-1/IL-1ß signaling pathway.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterus / Vinca Alkaloids / Gentamicins / Signal Transduction / Oxidative Stress / Caspase 1 / Interleukin-1beta / Inflammasomes Limits: Animals Language: En Journal: Mol Biol Rep Year: 2024 Document type: Article Affiliation country: Egypt
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterus / Vinca Alkaloids / Gentamicins / Signal Transduction / Oxidative Stress / Caspase 1 / Interleukin-1beta / Inflammasomes Limits: Animals Language: En Journal: Mol Biol Rep Year: 2024 Document type: Article Affiliation country: Egypt