Roles of negative emotions and personality traits in psoriasis vulgaris: A mendelian randomization study.
Skin Res Technol
; 30(5): e13702, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38743386
ABSTRACT
BACKGROUND:
Many studies have indicated that negative emotions and personality traits are related to psoriasis, though few have provided causal evidence.METHODS:
Our analysis utilized 15 genome-wide association study datasets to identify instrumental variables associated with negative emotions, personality traits and psoriasis vulgaris. Two-sample Mendelian randomization was conducted to identify the causal associations of negative emotions and personality traits with psoriasis vulgaris. To mitigate bias from multiple tests, we adjusted p-values using the Benjamini-Hochberg method.RESULTS:
Our study revealed causal links between negative emotions and psoriasis vulgaris, including depressed affect, worry too long, feeling hurt, guilty feelings, mood swings, unenthusiasm, miserableness, fed-up feelings. However, there was no significant evidence of a causal relationship between feeling lonely and psoriasis vulgaris. Additionally, personality traits including neuroticism and openness to experience were found to have causal effects on psoriasis vulgaris. However, no significant evidence supported a causal relationship between agreeableness, conscientiousness, and extraversion with psoriasis vulgaris.CONCLUSION:
Our findings suggest that experiencing negative emotions including depressed affect, worrying excessively, feeling hurt, guilty feelings, mood swings, lack of enthusiasm, miserableness and fed-up feelings may pose risks for psoriasis vulgaris. Additionally, neuroticism is associated with a risk of psoriasis vulgaris. Conversely, the openness trait may serve a protective role against psoriasis vulgaris.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Personality
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Psoriasis
/
Emotions
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Genome-Wide Association Study
/
Mendelian Randomization Analysis
Limits:
Humans
Language:
En
Journal:
Skin Res Technol
Journal subject:
DERMATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
China