Preparation and comparison of binary and ternary inclusion complexes of aripiprazole using L-arginine/lysine and MßCD/HPßCD by using different molar ratios.
Pak J Pharm Sci
; 37(1(Special)): 245-255, 2024 Jan.
Article
in En
| MEDLINE
| ID: mdl-38747276
ABSTRACT
Aripiprazole (ARI), an antipsychotic having low solubility and stability. To overcome this, formation of binary and ternary using inclusion complexes of Methyl-ß-cyclodextrin (MßCD) /Hydroxy propyl beta cyclodextrin (HPßCD) and L-Arginine (ARG)/ Lysine (LYS) are analyzed by dissolution testing and phase stability study along with their complexation efficacy and solubility constants made by physical mixing. Inclusion complexes with ARG were better than LYS and prepared by solvent evaporation and lyophilization method as well. They are characterized by Attenuated Total Reflection Fourier Transform Infrared Spectroscopy (AT-FTIR), X-ray powder diffractometry (XRD), Differential Scanning Calorimetry (DSC), Scanning electron microscopy (SEM) and Thermal gravimetric analysis (TGA). The bond shifting in AT-FTIR confirmed the molecular interactions between host and guest molecules. The SEM images also confirmed a complete change of drug morphology in case of ternary inclusion complexes prepared by lyophilization method for both the polymers. ARI MßCD ARG when used in the specific molar ratio of 110.27 by prepared by lyophilization method has 18 times best solubility while ARIHPßCDARG was 7 times best solubility than pure drug making MßCD a better choice than HPßCD. Change in the molar ratio will cause loss of stability or solubility. Solvent evaporation gave significant level of solubility but less stability.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arginine
/
Solubility
/
Calorimetry, Differential Scanning
/
Beta-Cyclodextrins
/
Aripiprazole
/
2-Hydroxypropyl-beta-cyclodextrin
/
Lysine
Language:
En
Journal:
Pak J Pharm Sci
Journal subject:
FARMACIA
/
FARMACOLOGIA
/
QUIMICA
Year:
2024
Document type:
Article
Affiliation country:
Pakistan