Recent advances in CAR T-cell engineering using synthetic biology: Paving the way for next-generation cancer treatment.
Adv Protein Chem Struct Biol
; 140: 91-156, 2024.
Article
in En
| MEDLINE
| ID: mdl-38762281
ABSTRACT
This book chapter highlights a comprehensive exploration of the transformative innovations in the field of cancer immunotherapy. CAR (Chimeric Antigen Receptor) T-cell therapy represents a groundbreaking approach to treat cancer by reprogramming a patient immune cells to recognize and destroy cancer cells. This chapter underscores the critical role of synthetic biology in enhancing the safety and effectiveness of CAR T-cell therapies. It begins by emphasizing the growing importance of personalized medicine in cancer treatment, emphasizing the shift from one-size-fits-all approaches to patient-specific solutions. Synthetic biology, a multidisciplinary field, has been instrumental in customizing CAR T-cell therapies, allowing for fine-tuned precision and minimizing unwanted side effects. The chapter highlights recent advances in gene editing, synthetic gene circuits, and molecular engineering, showcasing how these technologies are optimizing CAR T-cell function. In summary, this book chapter sheds light on the remarkable progress made in the development of CAR T-cell therapies using synthetic biology, providing hope for cancer patients and hinting at a future where highly personalized and effective cancer treatments are the norm.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Synthetic Biology
/
Receptors, Chimeric Antigen
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Adv Protein Chem Struct Biol
Journal subject:
BIOLOGIA
/
BIOQUIMICA
Year:
2024
Document type:
Article
Affiliation country:
India
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS