Recurrent ETV6::SYK rearrangement in myeloid malignancies confers partial susceptibility to MEK inhibition.

Manuelyan, Karen; Momcheva, Irina; Angelova, Svetlana; Nikolov, Krasimir; Shivarov, Velizar

Manuelyan, Karen; Momcheva, Irina; Angelova, Svetlana; Nikolov, Krasimir; Shivarov, Velizar.

Affiliation

Manuelyan K; Department of Dermatology and Venereology, Medical Faculty, Trakia University and UMHAT "Prof. Dr. St. Kirkovich", Stara Zagora, Bulgaria.
Momcheva I; Department of Rheumatology Burgas, University "Prof. Dr. Asen Zlatarov" Burgas and UMHAT Burgas, Burgas, Bulgaria.
Angelova S; Laboratory of Cytogenetics and Molecular Biology, National Haematology Hospital, Sofia, Bulgaria.
Nikolov K; Department of Medical Oncology, Complex Oncology Center, Burgas, Bulgaria.
Shivarov V; Department of Experimental Research, Medical University Pleven, Pleven, Bulgaria.

Br J Haematol ; 205(1): 382-386, 2024 Jul.

Article in En | MEDLINE | ID: mdl-38763512

Subject(s)

ETS Translocation Variant 6 Protein; Proto-Oncogene Proteins c-ets; Repressor Proteins; Syk Kinase; Humans; Syk Kinase/antagonists & inhibitors; Syk Kinase/genetics; Repressor Proteins/genetics; Proto-Oncogene Proteins c-ets/genetics; Oncogene Proteins, Fusion/genetics; Protein Kinase Inhibitors/therapeutic use; Protein Kinase Inhibitors/pharmacology; Gene Rearrangement; Male; Female; Middle Aged; Myeloproliferative Disorders/genetics; Myeloproliferative Disorders/drug therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Proto-Oncogene Proteins c-ets / Syk Kinase / ETS Translocation Variant 6 Protein Limits: Female / Humans / Male / Middle aged Language: En Journal: Br J Haematol Year: 2024 Document type: Article Affiliation country: Bulgaria

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