5-Fluorouracil Induced Hypertriglyceridemia During the Colorectal Cancer Treatment in a Patient With Multifactorial Chylomicronemia Syndrome: A Case Report.
Clin Ther
; 46(5): 429-432, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38763818
ABSTRACT
PURPOSE:
The case of a 47-year-old female patient who underwent sigmoidectomy for metastatic colorectal cancer is reported. Treatment with capecitabine and 5-fluorouracil induced severe hypertriglyceridemia repeatedly.METHODS:
Based on laboratory tests and clinical evaluations, treatment was suggested by specialists.FINDINGS:
After treatment with capecitabine, the patient's triglycerides increased from 19.7 mmol/L to 42 mmol/L. It was proposed that the patient had multifactorial chylomicronemia syndrome triggered by secondary factors. Statins, fenofibrate, ezetimib, and metformin were added to the therapy. After metastases appeared, FOLFIRI (leucovorin calcium [folinic acid], 5-fluorouracil, and irinotecan hydrochloride) chemotherapy and biological treatment (cetuximab) followed and triglycerides increased to 55.3 mmol/L. IMPLICATIONS Monitoring triglyceride levels before and during therapy is suggested.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Colorectal Neoplasms
/
Hypertriglyceridemia
/
Fluorouracil
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Clin Ther
Year:
2024
Document type:
Article