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The new seriniquinone glycoside by biological transformation using the deep sea-derived bacterium Bacillus licheniformis KDM612.
Okamura, Ryota; Kikuchi, Katsuki; Taniguchi, Akito; Nagai, Kenichiro; Seki, Reiko; Ohte, Satoshi; Ohshiro, Taichi; Ando, Masashi; Tanaka, Teruyoshi; Fukuda, Takashi.
Affiliation
  • Okamura R; Department of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
  • Kikuchi K; Department of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
  • Taniguchi A; Department of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
  • Nagai K; Microbial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
  • Seki R; Microbial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
  • Ohte S; Microbial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
  • Ohshiro T; Microbial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
  • Ando M; Department of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
  • Tanaka T; Department of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
  • Fukuda T; Department of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan. fukudata@nara.kindai.ac.jp.
J Antibiot (Tokyo) ; 77(8): 515-521, 2024 08.
Article in En | MEDLINE | ID: mdl-38773230
ABSTRACT
Seriniquinone was isolated as a melanoma-selective anti-cancer agent from a culture broth of the marine-derived bacterium Serinicoccus marinus CNJ927 in 2014. It targets the unique small protein, dermcidin, which affects the drug resistance of cancer cells. Due to its significant activity against cancer cells, particularly melanoma, and its unique target, seriniquinone has been developed as a new pharmacophore. However, it has the disadvantage of poor solubility in drug discovery research, which needs to be resolved. A new seriniquinone glycoside (1) was synthesized by the biological transformation of seriniquinone using the deep sea-derived bacterium Bacillus licheniformis KDM612. Compound 1 exhibited selective anti-cancer activity against melanoma, similar to seriniquinone, and was 50-fold more soluble in DMSO than seriniquinone.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacillus licheniformis / Glycosides / Antineoplastic Agents Limits: Humans Language: En Journal: J Antibiot (Tokyo) Year: 2024 Document type: Article Affiliation country: Japan Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacillus licheniformis / Glycosides / Antineoplastic Agents Limits: Humans Language: En Journal: J Antibiot (Tokyo) Year: 2024 Document type: Article Affiliation country: Japan Country of publication: United kingdom