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SARS-CoV-2 omicron BA.2.87.1 exhibits higher susceptibility to serum neutralization than EG.5.1 and JN.1.
Wang, Qian; Guo, Yicheng; Schwanz, Logan T; Mellis, Ian A; Sun, Yiwei; Qu, Yiming; Urtecho, Guillaume; Valdez, Riccardo; Stoneman, Emily; Gordon, Aubree; Wang, Harris H; Ho, David D; Liu, Lihong.
Affiliation
  • Wang Q; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Guo Y; Pandemic Research Alliance unit at the Wu Family Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Schwanz LT; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Mellis IA; Department of Pathobiology and Mechanisms of Disease, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Sun Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Qu Y; Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Urtecho G; Department of Biomedical Informatics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Valdez R; Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Stoneman E; Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Gordon A; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Wang HH; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
  • Ho DD; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
  • Liu L; Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Emerg Microbes Infect ; 13(1): 2359004, 2024 Dec.
Article in En | MEDLINE | ID: mdl-38779718
ABSTRACT
As SARS-CoV-2 continues to spread and mutate, tracking the viral evolutionary trajectory and understanding the functional consequences of its mutations remain crucial. Here, we characterized the antibody evasion, ACE2 receptor engagement, and viral infectivity of the highly mutated SARS-CoV-2 Omicron subvariant BA.2.87.1. Compared with other Omicron subvariants, including EG.5.1 and the current predominant JN.1, BA.2.87.1 exhibits less immune evasion, reduced viral receptor engagement, and comparable infectivity in Calu-3 lung cells. Intriguingly, two large deletions (Δ15-26 and Δ136-146) in the N-terminal domain (NTD) of the spike protein facilitate subtly increased antibody evasion but significantly diminish viral infectivity. Collectively, our data support the announcement by the USA CDC that the public health risk posed by BA.2.87.1 appears to be low.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Neutralizing / Immune Evasion / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Limits: Humans Language: En Journal: Emerg Microbes Infect Year: 2024 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Neutralizing / Immune Evasion / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Limits: Humans Language: En Journal: Emerg Microbes Infect Year: 2024 Document type: Article Affiliation country: United States