The Role of Anti-Müllerian Hormone in Ovarian Function.
Semin Reprod Med
; 42(1): 15-24, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38781987
ABSTRACT
Anti-Müllerian hormone (AMH) is a member of the transforming growth factor ß (TGFß) superfamily, whose actions are restricted to the endocrine-reproductive system. Initially known for its role in male sex differentiation, AMH plays a role in the ovary, acting as a gatekeeper in folliculogenesis by regulating the rate of recruitment and growth of follicles. In the ovary, AMH is predominantly expressed by granulosa cells of preantral and antral follicles (i.e., post primordial follicle recruitment and prior to follicle-stimulating hormone (FSH) selection). AMH signals through a BMP-like signaling pathway in a manner distinct from other TGFß family members. In this review, the latest insights in AMH processing, signaling, its regulation of spatial and temporal expression pattern, and functioning in folliculogenesis are summarized. In addition, effects of AMH variants on ovarian function are reviewed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovary
/
Signal Transduction
/
Anti-Mullerian Hormone
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Semin Reprod Med
Journal subject:
MEDICINA REPRODUTIVA
Year:
2024
Document type:
Article
Affiliation country:
Netherlands
Country of publication:
United States