Infection and Pediatric Arterial Ischemic Stroke Presumably Related to Focal Cerebral Arteriopathy: Data From the COVID-19 Pandemic.
Stroke
; 55(6): 1672-1675, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38787929
ABSTRACT
BACKGROUND:
Infection may trigger pediatric arterial ischemic stroke (PAIS), notably when related to focal cerebral arteriopathy. Community- and individual-level nonpharmaceutical interventions during the COVID-19 pandemic resulted in a major decrease in pediatric viral infections. We explored the consequences on the incidence of PAIS.METHODS:
Using national public health databases, we identified children hospitalized between 2015 and 2022 with PAIS. Using an age proxy (29 days to 7 years) and excluding patients with cardiac and hematologic conditions, we focused on children with PAIS presumably related to focal cerebral arteriopathy or with no definite cause. Considering the delay between infection and PAIS occurrence, we compared a prepandemic reference period, a period with nonpharmaceutical interventions, and a post-nonpharmaceutical intervention period.RESULTS:
Interrupted time-series analyses of the monthly incidence of PAIS in this group showed a significant decrease in the nonpharmaceutical intervention period compared with the prepandemic period -33.5% (95% CI, -55.2%, -1.3%); P=0.043.CONCLUSIONS:
These data support the association between infection and PAIS presumably related to focal cerebral arteriopathy.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ischemic Stroke
/
COVID-19
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
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Infant
/
Male
/
Newborn
Language:
En
Journal:
Stroke
Year:
2024
Document type:
Article
Country of publication:
United States