Updates in Translational Science for Esophageal and Gastric Cancers.
Surg Oncol Clin N Am
; 33(3): 571-581, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38789199
ABSTRACT
In this article, the authors summarize the current state of translational science for esophageal and gastric cancers. The available targeted therapies, immunotherapies, and recently discovered molecular targets are reviewed. The authors introduce circulating tumor deoxyribonucleic acid and its promise as a biomarker to detect disease recurrence. The authors present patient-derived organoids as a new model for studying carcinogenesis and treatment responses. Finally, we discuss the implications of organoid models for precision oncology and describe exciting new work applying gene editing technology to organoids and studying tumor-microenvironment interactions using 3-dimensional co-culture systems.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
Esophageal Neoplasms
/
Translational Science, Biomedical
Limits:
Animals
/
Humans
Language:
En
Journal:
Surg Oncol Clin N Am
/
Surg. oncol. clin. N. Am
/
Surgical oncology clinics of North America
Journal subject:
NEOPLASIAS
Year:
2024
Document type:
Article
Country of publication:
United States