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Molecular understanding and clinical outcomes of CAR T cell therapy in the treatment of urological tumors.
Zhang, Gong; Wang, Yuan; Lu, Shiyang; Ding, Fengzhu; Wang, Xia; Zhu, Chunming; Wang, Yibing; Wang, Kefeng.
Affiliation
  • Zhang G; Department of Urology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
  • Wang Y; Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
  • Lu S; Department of Urology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
  • Ding F; Department of Nursing, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
  • Wang X; Department of Urology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
  • Zhu C; Department of Family Medicine, Shengjing Hospital of China Medical University, Shenyang, 110004, China. chunmzhu@126.com.
  • Wang Y; Department of Urology, Shengjing Hospital of China Medical University, Shenyang, 110004, China. yibing_wang2015@126.com.
  • Wang K; Department of Urology, Shengjing Hospital of China Medical University, Shenyang, 110004, China. wang.kefeng@hotmail.com.
Cell Death Dis ; 15(5): 359, 2024 May 24.
Article in En | MEDLINE | ID: mdl-38789450
ABSTRACT
Chimeric antigen receptor engineered T (CAR T) cell therapy has developed rapidly in recent years, leading to profound developments in oncology, especially for hematologic malignancies. However, given the pressure of immunosuppressive tumor microenvironments, antigen escape, and diverse other factors, its application in solid tumors is less developed. Urinary system tumors are relatively common, accounting for approximately 24% of all new cancers in the United States. CAR T cells have great potential for urinary system tumors. This review summarizes the latest developments of CAR T cell therapy in urinary system tumors, including kidney cancer, bladder cancer, and prostate cancer, and also outlines the various CAR T cell generations and their pathways and targets that have been developed thus far. Finally, the current advantages, problems, and side effects of CAR T cell therapy are discussed in depth, and potential future developments are proposed in view of current shortcomings.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunotherapy, Adoptive / Urologic Neoplasms / Receptors, Chimeric Antigen Limits: Animals / Humans Language: En Journal: Cell Death Dis Year: 2024 Document type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunotherapy, Adoptive / Urologic Neoplasms / Receptors, Chimeric Antigen Limits: Animals / Humans Language: En Journal: Cell Death Dis Year: 2024 Document type: Article Affiliation country: China