Voltage Sensors Embedded in G Protein-Coupled Receptors.
Int J Mol Sci
; 25(10)2024 May 13.
Article
in En
| MEDLINE
| ID: mdl-38791333
ABSTRACT
Some signaling processes mediated by G protein-coupled receptors (GPCRs) are modulated by membrane potential. In recent years, increasing evidence that GPCRs are intrinsically voltage-dependent has accumulated. A recent publication challenged the view that voltage sensors are embedded in muscarinic receptors. Herein, we briefly discuss the evidence that supports the notion that GPCRs themselves are voltage-sensitive proteins and an alternative mechanism that suggests that voltage-gated sodium channels are the voltage-sensing molecules involved in such processes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, G-Protein-Coupled
/
Voltage-Gated Sodium Channels
Limits:
Animals
/
Humans
Language:
En
Journal:
Int J Mol Sci
Year:
2024
Document type:
Article
Affiliation country:
Israel
Country of publication:
Switzerland