CEACAM6 expression and function in tumor biology: a comprehensive review.
Discov Oncol
; 15(1): 186, 2024 May 25.
Article
in En
| MEDLINE
| ID: mdl-38796667
ABSTRACT
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an immunoglobulin superfamily protein primarily expressed on epithelial surfaces and myeloid cells. It plays a significant role in cancer progression by inhibiting apoptosis, promoting drug resistance, and facilitating cancer cell invasion and metastasis. Overexpression of CEACAM6 has been observed in various cancers, including lung, breast, colorectal, and hepatocellular cancers, and is associated with poorer overall survival and disease-free survival. Its differential expression on tumor cell surfaces makes it a promising cancer marker. This review aims to provide a comprehensive summary of CEACAM6's role in different cancer types, its involvement in signaling pathways, and recent advancements in CEACAM6-targeted treatments.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Discov Oncol
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United States