Biology of Variola Virus.
Adv Exp Med Biol
; 1451: 139-149, 2024.
Article
in En
| MEDLINE
| ID: mdl-38801576
ABSTRACT
Variola virus is an anthroponotic agent that belongs to the orthopoxvirus family. It is an etiological agent of smallpox, an ancient disease that caused massive mortality of human populations. Twentieth century has witnessed the death of about 300 million people due to the unavailability of an effective vaccine. Early detection is the primary strategy to prevent an outbreak of smallpox. Variola virus forms the characteristic pus-filled pustules and centrifugal rash distribution in the infected patients while transmission occurs mainly through respiratory droplets during the early stage of infection. No antiviral drugs are approved for variola virus till date. Generation of first-generation vaccines helped in the eradication of smallpox which was declared by the World Health Organization.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Variola virus
/
Smallpox
Limits:
Animals
/
Humans
Language:
En
Journal:
Adv Exp Med Biol
Year:
2024
Document type:
Article
Affiliation country:
India
Country of publication:
United States