Your browser doesn't support javascript.
loading
Human exposure characteristics of pharmaceutical and personal care product chemicals and associations with dietary habits.
Zheng, Yawen; Zhang, Lei; Xiang, Qian; Li, Jingguang; Yao, Yiming; Sun, Hongwen; Zhao, Hongzhi.
Affiliation
  • Zheng Y; Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China.
  • Zhang L; Research Unit of Food Safety, Chinese Academy of Medical Sciences, NHC Key Lab of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment (CFSA), Beijing 100021, China.
  • Xiang Q; Healthcare-associated Infection Control Center, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan, China.
  • Li J; Research Unit of Food Safety, Chinese Academy of Medical Sciences, NHC Key Lab of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment (CFSA), Beijing 100021, China.
  • Yao Y; Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China.
  • Sun H; Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China.
  • Zhao H; Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China. Electronic address: hongzhizhao@nankai.edu.cn.
Sci Total Environ ; 939: 173540, 2024 Aug 20.
Article in En | MEDLINE | ID: mdl-38806129
ABSTRACT
Considering the widespread presence of pharmaceutical and personal care products (PPCPs) in the environment and their adverse health effects, human exposure to PPCPs has caused worldwide concern. However, there remains insufficient information on the exposure assessment of the Chinese population. Based on this, the exposure levels of 13 PPCPs in the urine samples of 986 Chinese adults were measured, aiming to provide information on the prevalence of PPCP occurrence and investigate potential correlations between PPCP exposure and obesity. Results showed that the detection rates of these compounds in urine ranged from 28.12 % to 98.58 %, with median concentrations ranging below the limit of detection to 10.58 ng mL-1. Methyl-paraben (MeP) was the most dominant paraben and had the highest urinary concentration (median = 10.12 ng mL-1), while 4-hydroxy-benzophenone (4-OH-BP) was the dominant benzophenone derivative (median = 0.22 ng mL-1). In antibacterials, the urinary concentration of triclosan (mean = 42.00 ng mL-1) was much higher than that of triclocarban (mean = 0.63 ng mL-1). PPCP concentrations were significantly associated with sex, age, body mass index, education level, and annual household income (p < 0.050). Regression analysis of dietary habits showed that seafood and tea consumption may be significant exposure sources of PPCP exposure (p < 0.050). Furthermore, individual exposure to MeP (odds ratio (OR) < 1, p = 0.002) and 4-OH-BP (OR < 1, p = 0.009) exhibited a significantly negative association with obesity in females. Also, analysis results from quantile g-computation and Bayesian kernel machine regression models demonstrated that an inverse correlation between PPCP mixture exposure and obesity was significant in females. This study reports the extensive prevalence of PPCP exposure among adults from China, and may provide crucial insights into PPCP exposure dynamics. More epidemiological studies are need in the future, with a thorough knowledge of PPCP exposure.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cosmetics / Environmental Exposure Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Sci Total Environ Year: 2024 Document type: Article Affiliation country: China Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cosmetics / Environmental Exposure Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Sci Total Environ Year: 2024 Document type: Article Affiliation country: China Country of publication: Netherlands