The impact of low-dose methotrexate on erectile dysfunction, sex hormone profile and spermiogram in male patients with psoriasis: a prospective study.
Cutan Ocul Toxicol
; 43(3): 161-166, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-38810266
ABSTRACT
PURPOSE:
Psoriasis, affecting approximately 2% of the world's population, often necessitates systemic treatments, with methotrexate (MTX) as a cornerstone therapy. Despite documented systemic side effects of MTX, concerns about its impact on male reproductive health persist. We aim to investigate low-dose MTX effect on hormonal, cellular and functional ability of male reproductive system. MATERIALS ANDMETHODS:
Our prospective study on 40 male psoriasis patients receiving low-dose MTX (<15mg/week) comprehensively investigates its effects on erectile function, sex hormones, and spermiogram parameters.RESULTS:
After six months of MTX treatment, a significant decline in erectile function (p < 0.001) decreased total testosterone levels (p = 0.03) were observed. No significant reduction in sperm count was noted after six months of MTX treatment.CONCLUSIONS:
Our study highlights a significant decline in erectile function following low-dose MTX therapy, warranting further investigation into this potential side effect. While reassuring for sperm quantity and quality, the findings emphasise the necessity for larger cohorts and longer follow-up times to validate results and comprehend the complex interactions between MTX and male sexual health.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Psoriasis
/
Testosterone
/
Methotrexate
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Erectile Dysfunction
Limits:
Adult
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Cutan Ocul Toxicol
Journal subject:
DERMATOLOGIA
/
OFTALMOLOGIA
/
TOXICOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Turkey
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
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UK
/
UNITED KINGDOM