Dietary diversity score and the acceleration of biological aging: a population-based study of 88,039 participants.
J Nutr Health Aging
; 28(6): 100271, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38810510
ABSTRACT
OBJECTIVES:
Our study aimed to investigate the association of dietary diversity score (DDS), as reflected by five dietary categories, with biological age acceleration.DESIGN:
A cross-sectional study. SETTING ANDPARTICIPANTS:
This study included 88,039 individuals from the UK Biobank.METHODS:
Biological age (BA) was assessed using Klemerae-Doubal (KDM) and PhenoAge methods. The difference between BA and chronological age represents the age acceleration (AgeAccel), termed as "KDMAccel" and "PhenoAgeAccel". AgeAccel > 0 indicates faster aging. Generalized linear regression models were performed to assess the associations of DDS with AgeAccel. Similar analyses were performed for the five dietary categories.RESULTS:
After adjusting for multiple variables, DDS was inversely associated with KDMAccel (ßHigh vs Low= -0.403, 95%CI -0.492 to -0.314, P < 0.001) and PhenoAgeAccel (ßHigh vs Low= -0.545, 95%CI -0.641 to -0.450, P < 0.001). Each 1-point increment in the DDS was associated with a 4.4% lower risk of KDMAccel and a 5.6% lower risk of PhenoAgeAccel. The restricted cubic spline plots demonstrated a non-linear dose-response association between DDS and the risk of AgeAccel. The consumption of grains (ßKDMAccel = -0.252, ßPhenoAgeAccel = -0.197), vegetables (ßKDMAccel = -0.044, ßPhenoAgeAccel = -0.077) and fruits (ßKDMAccel = -0.179, ßPhenoAgeAccel = -0.219) was inversely associated with the two AgeAccel, while meat and protein alternatives (ßKDMAccel = 0.091, ßPhenoAgeAccel = 0.054) had a positive association (All P < 0.001). Stratified analysis revealed stronger accelerated aging effects in males, smokers, and drinkers. A strengthening trend in the association between DDS and AgeAccel as TDI quartiles increased was noted.CONCLUSIONS:
This study suggested that food consumption plays a role in aging process, and adherence to a higher diversity dietary is associated with the slowing down of the aging process.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Diet
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
J Nutr Health Aging
Journal subject:
CIENCIAS DA NUTRICAO
/
GERIATRIA
Year:
2024
Document type:
Article
Affiliation country:
China